Archives
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The first part of the study evaluated
2021-05-07
The first part of the study evaluated the accuracy of recomLine IgG and IgG Avidity to date CMV infection: In our study, 83.1% of samples tested matched onset dates compared to 71.9% with VIDAS avidity. Moreover, the number of inconclusive results (intermediate avidity for VIDAS, positive IgG withou
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77 8 br Acknowledgements We are grateful to the
2021-05-07
Acknowledgements We are grateful to the National Natural Science Foundation of China (Grant Nos. 21571033 and 81503099) and the New Drug Creation Project of the National Science and Technology Major Foundation of China (Grant No. 2015ZX09101032) for financial aids to this work. The research was a
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br Effects of estrogens on bone Estrogens
2021-05-07
Effects of estrogens on bone Estrogens play an important role in bone remodeling, as demonstrated by studies in mice in which the ER genes were deleted [21], [22]. ERβ compensates for the NAD+ of ERα, and vice versa, but when both ERs are deleted a profound decrease in trabecular bone volume is
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Of all ES cases approximately are metastatic diseases at dia
2021-05-07
Of all ES cases, approximately 26–28% are metastatic diseases at diagnosis with the remainder being localized disease [14]. Instituting a systemic chemotherapy regimen in combination with surgery and/or radiotherapy has significantly increased the survival of patients with localized disease. The 5-y
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In conclusion our findings suggested that EP receptor
2021-05-07
In conclusion, our findings suggested that EP4 receptor activation triggers apoptosis in B-cell lymphoblasts. Our results also showed that EP4 receptor engagement inactivates NF-κB, which, in turn, sensitizes Ramos ID-8 to apoptosis induced by chemotherapeutic agents. EP4 receptor agonists are curr
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br Results br Discussion In this study we investigated
2021-05-07
Results Discussion In this study, we investigated the role of EP4 on invasion and invadopodia in breast cancer cells. Our results demonstrate that EP4 activation promotes invadopodia-driven ECM degradation, in turn facilitating future intravasation and metastasis of breast cancer 5-aminosalicy
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Compound was prepared from chloroindole by acylation
2021-05-07
Compound was prepared from 6-chloroindole () () by acylation, to give , and subsequent reduction to give . The thiazole was then installed using conditions developed by Buchwald and co-workers to give . Hydrolysis of the ester yielded the thiazole Miconazole derivative (). Derivatives and were
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br Enzyme catalysis A biochemically spontaneous process proc
2021-05-07
Enzyme catalysis A biochemically spontaneous process proceeds in a direction where free pde inhibitors of the system decreases. However, every spontaneous or energetically favorable reaction needs to overcome an energy barrier known as the activation energy barrier because of the formation of an
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br Methods br Results br
2021-05-07
Methods Results Discussion I/R induces oxidative stress and increases the intracellular levels of ROS, resulting in tissue damage [31]. ROS is generated by mitochondrial electron transport chain, nicotinamide ion channels dinucleotide phosphate (NADPH) oxidase complex, xanthine oxidase and
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The biological actions of ET are
2021-05-07
The biological actions of ET‐1 are mediated via two distinct receptor subtypes, the endothelin A and endothelin B receptors (ETA/ETB). While activation of ETA is assumed to mediate contraction of smooth muscle cells, the activity of ETB is related to transient vasodilation [22]. In human corpus cave
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Dual inhibition of ACE and NEP as a strategy
2021-05-07
Dual inhibition of ACE and NEP as a strategy for treating hypertension has been extensively investigated, including contributions from these laboratories through the discovery of Sampatrilat . Given that both targets are related zinc metalloproteinases, dual enzyme inhibition can be achieved within
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Multiple protein species are known to
2021-05-07
Multiple protein species are known to naturally exist for the transmembrane receptors DDR1 and DDR2. Five splice variants have been characterized for DDR1 (“a” through “e”). The d and e isoforms lack the intracellular kinase domain of DDR1. The splicing of DDR1 to various extents has been reported i
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In summary we elucidated the in vitro activities
2021-05-07
In summary, we elucidated the in vitro activities of KDM1B in regulation of PC cell proliferation and apoptosis. These studies provided a novel insight into the previously unrecognized roles of KDM1B in human PC cells. We showed for the first time that KDM1B knockdown attenuated proliferation and in
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br Conflicts of interest br Financial support
2021-05-07
Conflicts of interest Financial support NZ is an Established Investigator of the Dutch Heart Foundation (2013T111) and is supported by an ERC Consolidator grant (617376) from the European Research Council and by a Vici grant from the Netherlands Organization for Scientific Research (NWO; 91818
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Introduction Ubiquitylation is a post translational modifica
2021-05-07
Introduction Ubiquitylation is a post-translational modification which impacts almost every biological process in the cell. Dysregulation of the ubiquitylation pathway is associated with several diseases, including cancer, neurodegenerative disorders, and immunological dysfunctions. Single ubiquiti