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In young animals the HT A receptor antagonist ketanserin at
2024-04-19
In young animals, the 5-HT2A 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium salt antagonist ketanserin, at relatively low concentrations, shifted 5-HT concentration-response curves rightward, suggesting a role for 5-HT2A receptors in mediating 5-HT-induced contractions of the ureter. The slopes
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br Acknowledgements This work was supported by grants from t
2024-04-19
Acknowledgements This work was supported by grants from the Program for Changjiang Scholars and Innovative Research Team in University (IRT_14R28), the National Basic Research Program of China (973) (Grant No.: 2013CB733602), the Major Research Plan of the National Natural Science Foundation of C
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WIN 64338 hydrochloride We have previously reported alterati
2024-04-19
We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center WIN 64338 hydrochloride (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, sugges
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Our analysis has devoted limited attention
2024-04-19
Our analysis has devoted limited attention to the standard corporate tax scheme with deductibility for interest payments that is in place in most countries. A conventional corporate tax scheme offers partial deduction of capital costs, and can be interpreted as a change in the degree of capital cost
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For both the hydroxylation and lyase reactions the
2024-04-19
For both, the 17α-hydroxylation and 17, 20-lyase reactions, the heme iron center of P450 17A1 receives electron reducing equivalents from CPR. Both reactions require one pair of electrons and molecular oxygen for the conversion of the substrate into product in each catalytic cycle. However, the 17,2
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Signaling through Axl can lead to activation of the PI
2024-04-19
Signaling through Axl can lead to activation of the PI3K/Akt and Ras/MAPK pathways which promote cellular phenotypes (e.g., transformation, migration) consistent with pro-survival and pro-metastatic effects., , Inhibition of Axl activity by a variety of approaches (including pharmacologic, dominant
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Previously several genes such as
2024-04-19
Previously, several genes such as cytokine (Lyu and Park, 2007), cell motility-associated genes (Schotterl et al., 2017), transforming growth factor-β (TGF-β), TGF-β receptor II which is a cell surface receptor with serine/threonine kinase activity (Jiang et al., 2014, Schotterl et al., 2017), cell
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br Structure of V ATPase V ATPase is a
2024-04-19
Structure of V-ATPase V-ATPase is a highly conserved multi-subunit enzyme that uses energy from ATP hydrolysis to transport protons across membranes [2], [3], [4]. It consists of two major functional domains, V1 and V0 (Fig. 1). The former has eight different subunits (A, B, C, D, E, F, G, and H)
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si cid To elucidate whether membrane fluidity changes could
2024-04-19
To elucidate whether membrane fluidity changes could impact on signaling pathways, we examined the effects of Rh2 on the activation of Akt, a lipid raft-associated protein kinase, which promotes cell survival and blocks the apoptotic pathways. Upon pretreatment with 5 mM MβCD and in the absence of R
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Our previous studies and others have identified
2024-04-19
Our previous studies and others have identified that the inhalational anesthetic isoflurane induces neuronal apoptosis via [Ca2+]i overload through the opening of synaptic voltage-dependent calcium channels (VDCCs) and the excessive Ca2+ release from the endoplasmic reticulum (Zhao et al., 2011; Zha
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Serum concentrations of acute phase proteins APP and of anti
2024-04-19
Serum concentrations of acute phase proteins (APP) and of antioxidants have proved to be clinically useful biomarkers of pyometra in different species, including bitches, cows and mares [[11], [12], [13], [14], [15]]. Acute phase proteins are being increasingly used in both human and veterinary medi
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br Experimental section br Acknowledgment S
2024-04-19
Experimental section Acknowledgment S.B.T. is grateful to the Deutsche Forschungsgemeinschaft (DFG), the Wilhelm Sander-Stiftung and Interdisciplinary Center for Molecular Materials (ICMM) for generous research support. M.M. greatly acknowledges the experimental support and the scientific cont
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The radiographic correlate will be
2024-04-19
The radiographic correlate will be similarly important for the success of other non-VEGF TKIs, such as those targeting the epidermal growth factor receptor expressed in 50% of high-grade primary 2-Deoxyadenosine 5-diphosphate synthesis neoplasms. It has been reported that icotinib and gefitinib, ep
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While there is structural information on the core of the
2024-04-18
While there is structural information on the core of the amyloid fibril, less is known about oligomer structure. There is evidence that the C-terminal of Aβ may form beta barrels in some oligomer species (Tay et al., 2013, Do et al., 2016), or may exist as loosely aggregated strands in other oligome
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br Materials and methods br
2024-04-18
Materials and methods Results Discussion Knowledge of the molecular basis of an inherited genetic disease is crucial for understanding the disease pathology and, ultimately, for therapeutic design. Several recent reports have stressed the need for physical characterization of disease-associ