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We and others have recently reported the therapeutic benefit
2018-11-14
We and others have recently reported the therapeutic benefits of propranolol in 2 patients with relapsing metastatic and multi-focal angiosarcoma, respectively (Banavali et al., 2015; Chow et al., 2015). Here, we extended these initial findings to 7 consecutive angiosarcoma patients with dismal prog
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A number of studies have demonstrated that oxidative injury
2018-11-14
A number of studies have demonstrated that oxidative injury in RPE cultures can be mitigated by compounds that exhibit antioxidant properties, including resveratrol (Chan et al., 2015). In contrast, we observed that piceatannol, a naturally occurring hydroxylated analog of resveratrol, promotes a su
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Hypothalamic hamartoma HH is a rare about
2018-11-14
Hypothalamic hamartoma (HH) is a rare (about 1:100,000) developmental, non-neoplastic malformation involving the small hypothalamic area located between the infundibular stalk and the mammillary bodies (). HH can be associated with a range of neurological and/or endocrinogical manifestations (). How
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THZ531 Most studies have been focused on investigating the m
2018-11-14
Most studies have been focused on investigating the molecular control of GPCR ubiquitination by identifying the E3 ubiquitin ligase, while the little information is available for deubiquitination of GPCR by deubiqutinating enzymes. Here we report that a deubiquitinating enzyme, USP11, promotes LPA1
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br Methods br Discussion We systematically searched the lite
2018-11-14
Methods Discussion We systematically searched the literature from the last five years to identify potential blood biomarkers for cancer (Hanahan & Weinberg, 2011; Cree, 2011). The data mining process retrieved 3990 citations from the initial 19, 724 records, screening the abstracts of these ci
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To date smallpox is the only infectious disease of humans
2018-11-14
To date, smallpox is the only infectious disease of humans that has been eradicated. A biological factor that favored smallpox eradication is the lack of a nonhuman reservoir. In scopolamine hydrobromide to smallpox, a yaws-like disease has been documented in various species of nonhuman primates (N
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In accordance with these observations we
2018-11-14
In accordance with these observations, we demonstrated the importance of a newly-identified stress response regulator, Usp2, both in Staphylococcal abscess lesion formation, albeit to a lesser extent than for the rshsyn mutant, and in biofilm formation. This correlates with recent studies that demon
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The complex interplay between viral escape and Env conformat
2018-11-14
The complex interplay between viral escape and Env conformation observed by Bradley et al. and others gives some pause to reductionist approaches focussing on recapitulating single bNAb specificities by immunisation. Favourable Gefitinib interactions between different bNAb epitopes, shown here for
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In a more than five year
2018-11-14
In a more than five-year-long study, we used a non-isogenic respiratory chain (RC) deficient mouse strain, namely the Harlequin (Hq) mouse, to test a set of drugs. We previously attributed the Hq mouse phenotype to a partial defect of RC complex I (CI) activity (Vahsen et al., 2004), due to a retrov
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br Data These data mainly focus on
2018-11-14
Data These data mainly focus on the dose-dependent neuroprotection provided by baclofen, memantine and l-carnitine against oxygen-glucose-deprivation (OGD)-related neurodegeneration of CA1 region, with an addition of the data obtained from the use of hypothermia instead of pharmacological agents.
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Only two studies have investigated
2018-11-14
Only two studies have investigated whether pubertal factors also influence white matter microstructure in adolescence, in addition to effects of age. The first study looked at RD in white matter tracts in males and females aged 8–28 years (n = 114, 63 females), and explored whether pubertal effects
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Our predictions were as follows Method br Results study
2018-11-13
Our predictions were as follows: Method Results study 1 To test whether variation in normative exposure to adverse early-life events was associated with children’s reward-based learning, we correlated Total Adversity scores computed from the ELEQ with reward and loss-related learning from PST t
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We have said little about
2018-11-13
We have said little about sex differences, but as is evident in Fig. 2, there are gender differences in sensation seeking (Cross et al., 2011), which will have implications for different types of risk taking during adolescence. The correlation between sensation seeking and impulsive action is consis
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Some sources engaged in stating the relationship between
2018-11-13
Some sources engaged in stating the relationship between the incidence of sleep disorders, and fatigue and tiredness despite getting enough sleep, and also the relationship between sleep disorders and hypo-gonadotropism and eventually decrease in free Mouse Angiopoietin-2 / ANG2 / ANGPT2 Protein (Hi
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The odor of different fresh shrimp
2018-11-13
The odor of different fresh shrimp was detected using electronic nose, the output of voltage of each sensor increased with acquisition time in the beginning, then got stable 2min later. The mean of the stable stage was indicated as output voltage of each gas sensor and used to analyze the odor chang
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