• Fig displays the comparison of the percentage of

  2018-10-25

  

  Fig. 4 displays the comparison of the percentage of subjects in these three groups between male and female. Male group had higher prevalence in borderline group and diabetic group, which was opposite in normal group (45.3% of male group vs 75.9% of female group). Also, the percentage of patients di

• br Conclusion Human BMSCs are a promising cell

  2018-10-24

  

  Conclusion Human BMSCs are a promising cell type for regenerative medicine and tissue-engineering applications. They have the capacity for self-renewal and exhibit multipotent differentiation potential through which they can produce lineages such as osteoblasts, chondrocytes, and adipocytes (Char

• We identified a number of CD markers that

  2018-10-24

  

  We identified a number of CD markers that are expressed in both osteoprogenitor and adipoprogenitor SW033291 Supplier and thus can be employed as core markers of the BMSCs phenotype. Our data corroborate previous studies that employed alternative technologies to identify markers for multipotent BMSC

• One of these factors SWI SNF

  2018-10-24

  

  One of these factors, SWI/SNF, is a large chromatin-remodeling complex that contains either BRG1 or BRM exclusively as the catalytic ATPase subunit that drives the alteration of DNA-nucleosome structure and thus regulates gene transcription (Fryer and Archer, 1998; Trotter and Archer, 2008; Wang et 

• Interestingly KLF and TFCP L

  2018-10-24

  

  Interestingly, KLF2 and TFCP2L1 are also involved in LIF/STAT3-mediated ESC self-renewal. KLF2, which is functionally redundant with KLF4, a known target of LIF/STAT3 signaling, can maintain mESCs in an undifferentiated state in the presence of serum (Hall et al., 2009). TFCP2L1, a key target of LIF

• We have previously used the distinctive HLA class

  2018-10-24

  

  We have previously used the distinctive HLA class I profile of VCT and EVT to characterize BMP-treated hESC (Bernardo et al., 2011). As a further refinement, we now show that we can distinguish between products of different HLA class I loci, particularly HLA-G and HLA-A and -B. With knowledge of the

• Introduction MicroRNAs miRNAs are small non coding RNAs that

  2018-10-24

  

  Introduction MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate the stability and translation of protein-coding transcripts through partial complementarity with their 3′ UTRs (Jaskiewicz and Filipowicz, 2008). There have been reports that miRNAs affect histone modifications or D

• ace inhibitor br Results br Discussion The

  2018-10-24

  

  Results Discussion The length of poly(A) tails plays an important role in controlling mRNA degradation and translational silencing, and is therefore dynamically regulated during development and disease (Eckmann et al., 2011; Norbury, 2013). A recent study showed that poly(A) tail length predom

• br Introduction Cardiac morphogenesis results from the speci

  2018-10-24

  

  Introduction Cardiac morphogenesis results from the specification, differentiation, and migration of spatially and temporally distinct sets of cardiac precursor 740 Y-P that give rise to the mature cardiac tissue. The first multipotent cardiogenic cells originate from the mesoderm formed at earl

• While we cannot exclude the

  2018-10-24

  

  While we cannot exclude the possibility that some MYB-dependent hematopoietic progenitor ras inhibitor (HPCs)/HSCs are generated during normal WT iPSC differentiation, we would expect a reduction in monocyte/macrophage production if the majority of monocytes/macrophages were derived from MYB-depend

• Homozygous GBA mutations are the

  2018-10-24

  

  Homozygous GBA1 mutations are the cause of the autosomal recessive lysosomal storage disorder Gaucher disease (GD). Both homozygous and heterozygous GBA1 mutation carriers have a similar risk for the development of PD in later life, although onset in GD patients may be earlier (Alcalay et al., 2014)

• The widespread hope for a new era of

  2018-10-24

  

  The widespread hope for a new era of prevention and treatment for chronic neurological disorders, such as stroke, Alzheimer\'s disease, and Parkinson\'s disease, will likely depend on the discovery of new CNS drugs. However, currently over 99% of candidate CNS drugs fail in clinical tests because of

• In the current study we devised

  2018-10-24

  

  In the current study, we devised simple refinements to the conventional culture condition of Kubota et al. (2004b) that promotes utilization of glycolysis, which we have termed GO (glycolysis-optimized) conditions. To achieve this, we removed all supplementation of lipids and free fatty acids from t

• br Results br Discussion PSC

  2018-10-24

  

  Results Discussion PSC offer great opportunities for human health, allowing the derivation of patient-specific tissues and providing disease models for drug screening. Thus, investigation of factors and mechanisms that regulate pluripotency constitutes a rapidly growing area of cutting-edge re

• hESC differentiation can shed light on developmental

  2018-10-24

  

  hESC differentiation can shed light on developmental and malignant processes. Neural progenitor cells derived from RB1-null hESCs did not differ significantly from control cells (Figure S3A), suggesting that a more complex differentiation paradigm is required to model pRB\'s tumorigenic and developm

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