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With regards to translational development of SMEPT we acknow
2020-06-12
With regards to translational development of SMEPT, we acknowledge that we are not aware of any trials currently underway to validate this methodology in clinical settings. It appears fair to say that enthusiasm and commitment from corporate developers does not match that of academic partners. One r
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Several effective strategies have been developed to design a
2020-06-12
Several effective strategies have been developed to design activatable MR probes according to the Solomon, Bloembergen and Morgan (SBM) theory, including modulation of the number of inner-sphere water molecules (q), the rotational tumbling time (τ) and the residence lifetime of inner-sphere water mo
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Due to the high attractiveness of E and E
2020-06-12
Due to the high attractiveness of E2 and E3 ligases as drug targets, a number of drug discovery assays have been published, based on detection by fluorescence (Dudgeon et al., 2010, Krist et al., 2016, Zhang et al., 2004), stavudine (Davydov et al., 2004, Huang et al., 2005, Kenten et al., 2005, Mar
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Besides the assessment of toxicological effects immediately
2020-06-12
Besides the assessment of toxicological effects immediately after exposure, we also studied the potential recovery of the exposed organisms, through the quantification of ChE activity at specific time intervals after placing organisms in clean test medium. Recovery from chemical challenge, in this c
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Determination of relative potency EC by dose response
2020-06-12
Determination of relative potency (EC50) by dose response assays in vitro is subject to the same sources of variability as determination of affinity, since the EC50 and Hill slope of the dose response curve are highly dependent on the binding of ligand to a competing receptor that may be present, an
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br Acknowledgement This research was
2020-06-11
Acknowledgement This research was supported by a grant from the National Research Foundation of Korea (NRF-2013R1A1A2011238) funded to Young-Mi Lee. Introduction Stroke is considered a serious disease with high morbidity and high mortality. More than 6 million deaths are reported each year wo
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Our study demonstrated that the sequential
2020-06-11
Our study demonstrated that the sequential events of PKA and AMPK activation were involved in kinsenoside-mediated lipolysis. Within 1 h, PKA transiently inhibited AMPK activation by mitigating LKB1-mediated AMPK phosphorylation at Thr172, and PKA reduced AMPK-mediated phosphorylation at HSL-Ser565
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br Conclusion br Acknowledgements br Introduction
2020-06-11
Conclusion Acknowledgements Introduction In recent years, fast progress has been made toward using the supercritical technology in industrial separation processes. Apart from a green extraction process that replaces organic solvents, applications involving supercritical fluids include super
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Organ fibrosis is thought to be initiated by repeated
2020-06-11
Organ fibrosis is thought to be initiated by repeated or chronic epithelial injury. The current belief is that damaged epithelial urotensin ii induce an aberrant and unresolved wound repair process by activating fibroblasts via various profibrotic cues. Upon injury, epithelial cells activate the pr
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Peptides undergoing only a single
2020-06-11
Peptides undergoing only a single hydroxylation, i.e. PA-Hyp-KPAPK and PAPK-Hyp-APK, were then used to investigate the kinetics of vCPH co-factor and co-substrate dependences. The values for KMapp for Fe(II) and KM for 2OG for the two peptide substrates were within error (KMapp, Fe(II): 0.9 μM ± 0.1
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br Acknowledgements br Introduction Water and electrolytes c
2020-06-11
Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and neuraminidase inhibitor governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in
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In rodent models the loss of estrogens through ovariectomy
2020-06-11
In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an Ticlopidine HCl receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide syntha
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br Conflict of interest br Supplementary methods and materia
2020-06-11
Conflict of interest Supplementary methods and materials Acknowledgments This work was supported by an Early Career Researcher grant awarded by the Institute of Health and Biomedical Innovation to IMW and Queensland University of Technology, and grants awarded to SS by the Prostate Cancer F
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br Introduction Epidermal growth factor
2020-06-11
Introduction Epidermal growth factor receptor (EGFR)-activating-mutant non-small cell lung cancer (NSCLC) often initially responds well to EGFR tyrosine kinase inhibitors (TKIs) (Haber et al., 2011); however, the disease almost always recurs about 10–13 months of therapy. Analysis of clinical spe
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Herein in continuation of our
2020-06-11
Herein, in continuation of our interest in designing new DNA photocleavage agents [18], we report the synthesis, characterization and DNA binding and cleaving properties of a novel compound: trans-N,N-dimethyl-10,11-di(pyridin-4-ium)-10,11-dihydro-9,12-dioxobenzo[e]phenanthrene tetrafluoroborate (1)
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