• Although effects of low concentrations of agonist

  2023-08-01

  

  Although effects of low concentrations of agonist were not as thoroughly documented for heteromeric receptors such as the major 5-Methoxy-CTP α4β2 nAChR, a similar mechanism of action was described to explain the potentiation of these receptors with low concentrations of acetylcholine-esterase-inhi

• It has been suggested that the suppression of

  2023-08-01

  

  It has been suggested that the suppression of 5-LOX could promote apoptotic signaling pathways in cancers [6]. However, the role of 5-LOX in modulating apoptotic factors and neutrophil activation during ANP has not yet been evaluated. In this study, we aimed to evaluate the expression of 5-LOX in pa

• br Materials and methods br Results br

  2023-08-01

  

  Materials and methods Results Discussion We have developed a high-throughput functional genomic screen that allows the identification of genes that confer drug resistance. Several factors have been identified which must be taken into account to develop a reliable screen. In particular, cons

• br Methods br Results br Discussion Autotaxin has been

  2023-08-01

  

  Methods Results Discussion Autotaxin has been shown to have effects on major cell types implicated in OA, notably chondrocytes, osteoblasts, osteoclasts, and synoviocytes, through its enzymatic product LPA [20]. However, a paucity of research exists on the involvement of autotaxin in OA. Fi

• br Materials and methods br Results br Discussion

  2023-08-01

  

  Materials and methods Results Discussion Recent studies have highlighted T7 High Yield RNA Synthesis and autophagy as novel targets for the treatment of liver fibrosis [7,14]. In this study, we demonstrated that catalpol protected the rat liver from CCl4-caused injury and fibrogenesis in v

• br Discussion In our current study

  2023-08-01

  

  Discussion In our current study, we demonstrated that both the metastatic and recurrent ovarian cancer tissues expressed lower levels of p62 when compared with the patient-matched primary tumor samples. High kainate receptors levels of p62 were associated with long progression-free survival of p

• br Diabetes and obesity fit or

  2023-08-01

  

  Diabetes and obesity: fit or fat; sugar or not: the autophagic verdict Type 2 diabetes and obesity are among the most emerging health problems worldwide. The factors that are responsible for the establishment of diabetes include decreased EW-7197 australia production, rise in adiposity, and an i

• Here we report discovery of highly

  2023-08-01

  

  Here we report discovery of highly selective pan-Aurora kinase inhibitors through phenotypic screening. The co-crystal structure of nitric oxide synthase inhibitors bound in the ATP binding site of Aurora A is described, and provides insight into the possible structural basis for the selectivity o

• dub ubiquitin While it is known that circulating LDL C level

  2023-08-01

  

  While it is known that circulating LDL-C levels are largely regulated by either controlling the rate of hepatic production of its triglyceride-rich precursor VLDL particle or the rate of LDLR-mediated LDL particle clearance [58], it should be noted that important differences exist between rodents an

• EPI-001 australia Exposure to cisplatin with ATR inhibitor r

  2023-08-01

  

  Exposure to cisplatin with ATR inhibitor resulted in an increase in cisplatin-DNA adducts, especially in cells with ATM deficiency. This finding indicates that suppressing ATR-Chk1 signaling with VE-822 enhances cisplatin activity by enabling the drug to form DNA adducts. Therefore, VE-822 may incre

• Chromatin proteins play important roles in gene expression

  2023-08-01

  

  Chromatin proteins play important roles in gene expression and DNA repair. The importance of chromatin composition on gene expression is exemplified by X-inactivation, where one of the two X chromosomes in female mammalian NSC59984 is transcriptionally silenced by heterochromatin , , , . In the ATR

• Why do glutamate and glycine bind to the receptor

  2023-08-01

  

  Why do glutamate and glycine bind to the alkaline phosphatase inhibitors in such different ways? Given the overall structural similarity between the GluN2A and GluN1 LBDs, one might conclude that the LBDs also bind ligands via similar processes. NMDA receptors with engineered disulfide linkages tha

• Furthermore low affinity sites that share no structural homo

  2023-08-01

  

  Furthermore, low-affinity sites that share no structural homology with the aforementioned sites have been described in the transmembrane domain. It has been discovered that, in α1βγ2 receptors, potentiation of GABA-activated currents by high concentrations of diazepam is biphasic, with a high- and a

• In our study S aureus activated the

  2023-08-01

  

  In our study, S. aureus activated the TLR signaling pathways of BMECs, thus inducing profibrogenic growth factor expression via NF-κB and AP-1. Since fibrosis is an important pathogenic process in both bovine and human mastitis, further studies on the molecular mechanisms of S. aureus infection are

• br Results br Discussion Control of chronic

  2023-08-01

  

  Results Discussion Control of chronic inflammation is important in several inflammatory conditions like asthma, rheumatoid arthritis and fibrosis in lung diseases. The regulatory pathways that control chronic inflammation are complex and multi-factorial. Over expression of inflammatory mediato

14260 records 145/951 page Previous Next First page 上5页 141142143144145 下5页 Last page