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Free fatty acids FFAs which are obtained from dietary fat
2022-08-19
Free fatty acids (FFAs), which are obtained from dietary fat or endogenous synthesis, function as nutrients and signaling molecules. Studies have shown that free fatty Sodium Danshensu receptors 1–4 which are G-protein coupled receptors, bind free fatty acids and serve as receptors for these FFAs. S
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2-D08 synthesis Classical drugs target the viral enzymes rev
2022-08-19
Classical drugs target the viral 2-D08 synthesis reverse transcriptase (RT), protease and integrase (IN) [[4], [5], [6]]. Raltegravir (ISENTRESS/MK-0518) is the prototypical integrase strand transfer inhibitor (INSTI) leading to an extremely strong reduction in viral load [7] and it has been approve
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Pharmacological G a inhibition resulted
2022-08-19
Pharmacological G9a inhibition resulted in significant reduction of viable BTC cells in a concentration- and cell line–dependent manner. Interestingly, we found a significant correlation between BIX01294-IC50 and UNC0642-IC50 values in our BTC cell model—both inhibitors competitively inhibit H3K9 su
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Traditional methods for HATs activity assays mainly depend o
2022-08-19
Traditional methods for HATs activity assays mainly depend on radioisotope labelling of histone substrates, which is limited by the complex procedures, hazards and wastes of radioactive materials. Hence, various alternative approaches such as electrochemical analysis, fluorescence and colorimetric a
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In recent years the Hippo signaling pathway has emerged as
2022-08-19
In recent years, the Hippo signaling pathway has emerged as an important regulator balancing cell proliferation and differentiation [[5], [6], [7]]. The pathway components, first described in the fruit fly Drosophila melanogaster, are highly conserved across different phyla [6]. The signaling pathw
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All the compounds and were
2022-08-19
All the compounds –, , , –, , – and – were assayed for their potential cytotoxicity at a single dose of 10 µM on Huh7 cells. Interestingly, all compounds proved to be non toxic, with the exception of and which exhibited high cellular toxicity and therefore were excluded from further experiments (a).
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Furthermore we also found that
2022-08-19
Furthermore, we also found that both activation of oncogenes and inactivation of tumor suppressor genes occurred in HBV oval cells, which showed opposite pattern in HBV hepatocytes. These genes might take part in neoplastic transformation of oval cells induced by HBV regarding the multipotent role o
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Acknowledgments The authors thank Partners Healthcare
2022-08-19
Acknowledgments The authors thank Partners Healthcare for financial support. This work was also supported in part by NIH Grant R01CA122608 to J.M.G.H. Introduction The phosphorylation of histone H3 is recognized as a hallmark of mitosis. Histone H3 phosphorylation at Thr3 (H3T3ph) acts as a mit
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br Conclusions br Introduction Astrocytes contribute to phys
2022-08-19
Conclusions Introduction Astrocytes contribute to physiological bcr-abl inhibitors function on many levels. They help maintain the physiological composition of the extracellular medium by, for instance, buffering potassium and uptake of neurotransmitters. They can also provide neurons with ene
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In recent years several DPP IV
2022-08-19
In recent years, several DPP-IV inhibitors have already been approved, such as sitagliptin, vildagliptin, saxagliptin, tenegliptin, alogliptin and linagliptin, etc. Among them, linagliptin (1, Fig. 1) is a non-peptide mimetic ZCL278 with a unique xanthine scaffold developed through high-throughput
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br Introduction Inflammatory bowel diseases IBDs
2022-08-19
Introduction Inflammatory bowel diseases (IBDs) including Crohn's disease and ulcerative colitis (Baumgart and Sandborn, 2012; Beaugerie et al., 2006) are typically characterized by chronic, progressive, and relapsing inflammation of the intestine. Although the exact pathogenesis of IBD is unknow
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Acknowledgements br Introduction The neurotransmitter glycin
2022-08-18
Acknowledgements Introduction The neurotransmitter glycine acts through two receptors: a strychnine-sensitive glycine receptor (GlyA) and a strychnine-insensitive glycine receptor (GlyB). GlyA is localized to the neuronal membrane post-synaptic to inhibitory glycinergic neurons, whereas GlyB is
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Overall ABC transporters are hypothesised to prevent
2022-08-18
Overall, ABC transporters are hypothesised to prevent the penetration of AEDs and other pharmacological compounds into the brain, being a hurdle for therapeutic delivery in neurological diseases. DRE is thought to be in part related to an increased expression of efflux transporters in the BBB, altho
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On the basis of their relative Glu transport
2022-08-18
On the basis of their relative Glu transport rates and anion currents, EAATs group into two functionally distinct classes, EAAT1–3 being efficient Glu transporters with small associated macroscopic anion currents and EAAT4–5 low-capacity transporters with predominant anion conductance [18]. The diff
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Results indicated that superfusion of
2022-08-18
Results indicated that superfusion of orexin alone, glutamate alone or orexin-glutamate co-administration significantly increases the spontaneous discharge rate of LC neurons in both morphine dependent and non-dependent rats (Fig. 2, Fig. 3). However, co-application of orexin and glutamate resulted
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