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Recently CFS has been included in
2022-05-20
Recently, CFS has been included in the group “low cystine and glutamine syndromes,” which are characterized by a combination of abnormally low plasma levels of these two aminoacids, as well as reduced natural killer cell activity, and increased rates of urea production [13]. Some studies indicated
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br Conclusion The development discovery of compounds targeti
2022-05-20
Conclusion The development/discovery of compounds targeting small GTPases is challenging [43,44]. Our data point to RBC8 being efficient and potent as a Ral inhibitor in human and mouse platelets, but that it exhibits some activity beyond just Rals, particularly in mouse platelets. It is however
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br GSK The GSK family is highly conserved throughout evoluti
2022-05-20
GSK-3 The GSK-3 family is highly conserved throughout evolution and is encoded by two genes, GSK-3α and GSK-3β, which are located in chromosomes 19q13.2 and 3q13.3 in human, respectively. Both GSK-3α and GSK-3β proteins exist in a variety of tissues with the highest levels found in CGP 55845 hydr
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Furthermore the role of GSK in the pathogenesis of
2022-05-20
Furthermore, the role of GSK-3 in the pathogenesis of inflammation has been widely documented as it accompanies inflammatory conditions such as diabetes mellitus, mood disorders, Alzheimer’s disease, cancer (Jope et al., 2007), and has been associated with atherothrombotic CVD events. However, anoth
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br Introduction The replacement of a regular
2022-05-20
Introduction The replacement of a regular intake of healthy oils and fibres for a diet based substantially on high fat- and high sugar-content foods has had profound consequences for public health. These changes in the way that the populations of high income, particularly Western countries, manag
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GPR is present primarily in the pancreas and the intestine
2022-05-20
GPR119 is present primarily in the pancreas and the intestine. Activation of GPR119 increases insulin, GLP-1, GIP and PYY secretion. GPR119 agonists stimulate insulin release in a glucose-dependent manner. The glucose dependent insulin secretion (GIDS) mechanism makes GPR119 an attractive target for
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br Conclusion The wild study reports
2022-05-20
Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and flavin adenine dinucleotide plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory behavior, higher
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We report here a patient
2022-05-19
We report here a patient with a one-base frame-shift deletion in the PURA gene that presented an unusual phenotype including persistent hypoglycorrhachia. We propose a possible link between hypoglycorrhachia and PURA dysfunction postulating PURA as a GLUT1 regulator. We therefore hypothesize that mu
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The Growth Hormone Secretagogue Receptor GHSR also
2022-05-19
The Growth Hormone Secretagogue Receptor (GHSR), also known as the ghrelin receptor, is a G protein-coupled receptor (GPCR) expressed widely throughout the body and brain, with particular enrichment in 4-Methylhistamine dihydrochloride regions concerned with homeostatic and motivational function suc
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A comparison of our results with literature
2022-05-19
A comparison of our results with literature data on the action of pregnane and androstane steroids on the functional activity of NMDAR, GABAAR and GlyR enables us to draw the following conclusions. First, androstane steroids (with no substituents at C-17) at a concentration up to 50 μM do not affect
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A majority of aptamer based biosensors termed
2022-05-19
A majority of aptamer-based biosensors (termed aptasensors) is based on structure-switching process of aptamer probes upon target binding [[12], [13], [14], [15]]. And canonical structure-switching aptamer probes are strand-displacement aptamer probes, aptamer beacons and split aptamers [[16], [17],
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In summary the SAR of a series
2022-05-19
In summary, the SAR of a series of phenylpropanoic acid-free fatty BCTC receptor agonists is described which resulted in the identification of potent FFA4 agonists. The superior pharmacokinetic properties of compound led to its selection as an in vivo tool compound which afforded robust efficacy i
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FBPase deficiency is a very rare inborn
2022-05-19
FBPase deficiency is a very rare inborn error of fructose Rose Bengal of autosomal recessive inheritance. This disorder usually occurs in the first year of life through ketotic hypoglycemia and lactic acidosis triggered by catabolic episodes such as prolonged fasting or febrile infections (Steinman
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In this paper we demonstrate a diatomaceous earth based
2022-05-19
In this paper, we demonstrate a Cy5 NHS ester (non-sulfonated) receptor based TLC-SERS sensing technique combined with machine learning analysis to quantitatively detect seafood allergen in real spoiled tuna samples. We fabricate a diatomaceous earth TLC plate as a separable SERS-active substrate t
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br Conclusion br Author contributions br Acknowledgements We
2022-05-19
Conclusion Author contributions Acknowledgements We thank cid calculator USC Center for Craniofacial Molecular Biology (CCMB) for their extensive guidance and teaching in biochemical techniques. We acknowledge Laurel Fisher, PhD for her contribution to statistical analysis of the data. We a
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