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br Acknowledgements br Introduction Three structurally relat
2019-09-11
Acknowledgements Introduction Three structurally related fungal metabolites have been isolated from chloroform extracts of submerged rice cultures of Aspergillus terreus 23-1 from stored unhulled rice in Taiwan; these were named territrems A–C to indicate their biological origin (A. terreus) a
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Herbal products may alter the metabolism of certain drugs
2019-09-11
Herbal products may alter the metabolism of certain drugs and, likewise, the metabolism of components of herbal products may be altered by some drugs, specifically those that affect cytochrome P450 Clozapine (CYP). These can bring about an alteration of the pharmacokinetics and pharmacological activ
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We also note that though the deletion of
2019-09-11
We also note that though the STK393606 of the N-terminus in Ube2E1∆N46 or the mutations in Ube2E16KtoR enhanced their activity compared to the wild type, it failed to match Ube2D2 (Fig. 1). We concluded this difference to be multi-factorial as none of the Ube2E1∆N46 point mutants involving “Ub back
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The differences between ground and transition state properti
2019-09-11
The differences between ground and transition state properties are exemplified by a comparison of our human–yeast results with those of a structural study of possible differences in ubiquitin-Uba-1 binding in yeast (known structure) with human (simulated in [12]). Their discussion focuses on Ubiquit
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DDR expression is upregulated in the glomeruli
2019-09-11
DDR1 expression is upregulated in the glomeruli and tubules of injured kidneys [7], [8], [19]; however, what role this receptor plays in kidney resident NG,NG-dimethyl-L-Arginine hydrochloride and is unclear. A plausible hypothesis is that DDR1 might contribute to kidney injury by directly exerting
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An intriguing feature of the
2019-09-11
An intriguing feature of the pre and postsynaptic processes at the level of the VTA that have been shown to be mediated by CRF2 receptors [9], [34] is that they are exerted only by agonists with high affinity for both CRF2 receptors and CRF-BP. The four endogenous peptides of the CRF system have hig
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br Conclusion br Acknowledgement The project was supported
2019-09-11
Conclusion Acknowledgement The project was supported by National Natural Science Foundation of China, China (No. 31872535); Natural Science Foundation of Shandong Province, China (ZR2018MC027, ZR2016CQ29); and Funds of Shandong \"Double Tops\" Program, China. Introduction High-altitude hyp
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Introduction Safety critical systems are defined as those sy
2019-09-11
Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated within
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The Fontan circulation When first described in
2019-09-11
The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital Cathepsin G Inhibitor I mass disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which c
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Determination of relative potency EC by dose response assays
2019-09-11
Determination of relative potency (EC50) by dose response assays in vitro is subject to the same sources of variability as determination of affinity, since the EC50 and Hill slope of the dose response curve are highly dependent on the binding of ligand to a competing receptor that may be present, an
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p is a tumor suppressor gene that inhibits cyclin
2019-09-10
p16 is a tumor-suppressor gene that inhibits cyclin-dependent kinase 4 and 6 activities and arrests the insulin pathway in the G1 phase. Aberrant methylation and mutation of p16/MTS1 in OSCC of patients was found in our previous study. Moreover, the frequency of hypermethylation of p16 from the pre
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br Materials and methods br Results and discussion br Conclu
2019-09-10
Materials and methods Results and discussion Conclusions Clitocypin is another member of the mycocypin family of cysteine protease inhibitors that is unique to formula for concentration shown to exhibit strong insecticidal activity against Colorado potato beetle larvae. This effect is conc
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Elevated production of cysLTs in asthma and rhinitis in gene
2019-09-10
Elevated production of cysLTs in Vanoxerine dihydrochloride and rhinitis in general and aspirin-sensitive disease in particular10, 11, 26, 27 has been implicated in causing epithelial cell activation and excessive mucus secretion, which characterize these diseases.2, 28 It is of particular interest
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br Acknowledgements br Introduction Chemokines are a superfa
2019-09-10
Acknowledgements Introduction Chemokines are a superfamily of chemotactic cytokines that play important roles in regulating cell migration and activation under inflammatory conditions (Nomiyama et al., 2008; Peatman and Liu, 2007; Zlotnik and Yoshie, 2000), such as angiogenesis (Arenberg et al
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br Acknowledgments The authors thank
2019-09-10
Acknowledgments The authors thank Elisabete Lepera and Rosana Silva for technical support. The study was supported by FAPESP, CNPq and PADC/FCF-UNESP. T.T. Miguel was the recipient of a FAPESP (Proc. 05/05171-1) and R.L. Nunes-de-Souza of a CNPq (Proc. 303580/2009-7) fellowship. Introduction