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Only a few studies have
2021-06-17
Only a few studies have examined the effect of prostanoids on cardiac fibroblasts. Therefore, this study examines the effect of PGE2 on cardiac fibroblast proliferation and tests the hypothesis that PGE2 causes cardiac fibroblast proliferation via alterations of Boc-D-Asp(OtBu)-OH.DCHA regulatory m
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Up to of the host B
2021-06-16
Up to 10% of the host Tanshinone I synthesis are infected with EBV during acute infectious mononucleosis. Most of these cells are effectively cleared by the immune system, but some downregulate viral gene expression and differentiate into safety in the resting memory B cell pool. In the persisting
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Increased levels of PCNA monoubiquitination by
2021-06-16
Increased levels of PCNA monoubiquitination by UbL73P expression in a damage-independent manner mimics the phenotype observed for USP1 knockdown (Huang et al., 2006, Jones et al., 2012). USP1 is the only DUB to date shown to remove ubiquitin from PCNA in vivo. This finding reveals the highly dynamic
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Another mechanism underlying on the toxicity of dopaminergic
2021-06-16
Another mechanism underlying on the toxicity of dopaminergic neurons might be related to dopamine-dependent initial oxidative stress [60]. Dopamine Z-DEVD-FMK mediated by monoamine oxidase (MAO) can produce hydrogen peroxide as a by-product, and excess dopamine can undergo auto-oxidation to quinones
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br Development of the double strand break repair model
2021-06-16
Development of the double strand break repair model for meiotic recombination Meiotic recombination was first described by Frans Alfons Janssens using fluoxetine hydrochloride in the salamander Batracoseps attenuatus in 1909 [21] and then further elaborated at the genetic level in Drosophila by T
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Data presented herein suggest that competent
2021-06-16
Data presented herein suggest that competent IL-18BP production in epithelial 7441 is implemented by epigenetic means based on demethylation of a single CpG site at −45 bp/−44 bp (CpG2) of the human IL18BP promoter. In contrast, retarded IL-18BP production in monocytic cells associates with CpG2 me
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br Materials and methods br Results br
2021-06-15
Materials and methods Results Discussion This study demonstrates that various progestogens combined with E2 had different effects on breast cell growth. These effects had an inverse correlation with the changes of the PRA/PRB ratio. E2's antiapoptotic effects on MCF-7 Sodium ascorbate may b
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One possible pitfall of using EPAC activators in
2021-06-15
One possible pitfall of using EPAC2 activators in the treatment of T2DM is their potential to increase glucagon levels. As discussed previously, although the ability of EPAC2 to increase glucagon expression and production is controversial, several studies show that this protein increases Gcg mRNA le
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Adding more pieces to the puzzle using a human to
2021-06-15
Adding more pieces to the puzzle, using a human-to-animal crossover study, blood taken from healthy volunteers that underwent exercise was used as a dialysate to perfuse a rabbit heart in a Langendorff model of MI [62]. Unprecedentedly, dialysate of plasma from exercised humans reduced infarct size
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The glycolytic pathway is a catabolic
2021-06-15
The glycolytic pathway is a catabolic route that ends with the synthesis of pyruvate (Pyr). In Arabidopsis embryos, the conversion of phosphoenolpyruvate (PEP) to Pyr, catalyzed by pyruvate kinase (PK), is mainly located in the plastids [10], [11]. The preceding reaction is catalyzed by enolase (ENO
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There are two types of DDRs DDR
2021-06-15
There are two types of DDRs, DDR1 and DDR2, which are type I transmembrane RTKs characterized by an N-terminal extracellular discoidin domain containing a collagen binding site [8]. DDR1 expression is somewhat restricted to epithelial cells, while DDR2 is often expressed in cells of mesenchymal orig
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Mammalian cells have two distinct DNA repair
2021-06-15
Mammalian caspofungin sale have two distinct DNA repair pathways for DSBs, NHEJ and HR. Our data are consistent with the suggestion that the DNA–PK-mediated NHEJ pathway recognizes DSBs faster than the HR pathway and acts before the activation of the DNA damage S-phase checkpoint. The activation of
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Mitochondrial depolarization induced by DHODH inhibition Fig
2021-06-15
Mitochondrial depolarization induced by DHODH inhibition (Figure 5A) may also contribute to the selective effects of DHODH inhibitors on KRAS mutant cells. If so, the effect may arise more from pro-apoptotic effects of mitochondrial depolarization (Lemasters et al., 1998) than from impaired oxidativ
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The cholinergic system has been
2021-06-11
The cholinergic system has been shown to play a role in regulation of the inflammatory response [13] as well as in the influence of the metabolism of PCa cells [14]. The reduced activity of cholinesterase (ChoE) and the consequent increased amount of rvx mg has been shown to lead to a cholinergic o
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It is well known that Doxorubicin
2021-06-11
It is well known that Doxorubicin-induced cardiotoxicity occurs via p53-mediated apoptosis (Lorusso et al., 2007). However, there are few studies elucidating the mechanism of HFS induced by PLD. We found that PLD induces keratinocyte apoptosis in a very low dose, and the damage induced by PLD cannot