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The Fontan circulation When first described in the
2020-11-09
The Fontan circulation When first described in 1971, the Fontan operation ushered in a new paradigm in the care of children born with the varied forms of complex congenital amphetamine sulfate disease (CHD) characterized by a single effective pumping chamber.1., 2. This procedure, which creates a
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br Clinical studies br Practical implications for
2020-11-09
Clinical studies Practical implications for young women Conclusion Research on the oncogenic mechanism of hormones has advanced dramatically in the latter years. The finding that progestogens are more powerful determinants of risk than estrogens in breast cancer has been added to advances i
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Although it was shown that IL
2020-11-09
Although it was shown that IL-23 signaling induces expression of T17 pathogenic signature genes through activation of STAT3,, transcription factors other than STAT3 are also implicated for induction of pathogenic T17 cells because IL-6, which activates STAT3 similarly to IL-23, cannot induce IL-23R
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chemokine receptor br Enzyme catalysis A biochemically spont
2020-11-09
Enzyme catalysis A biochemically spontaneous process proceeds in a direction where free chemokine receptor of the system decreases. However, every spontaneous or energetically favorable reaction needs to overcome an energy barrier known as the activation energy barrier because of the formation o
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br Acknowledgments This work was supported by
2020-11-09
Acknowledgments This work was supported by Région Auvergne “Nouveau chercheur”. This study has been performed with the assistance of Christelle Damon-Soubeyrand for histology technical assistance using “Anipath” Platform (GReD) and Sandrine Plantade, Keredine Ouchen and Philippe Mazuel for animal
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It is without doubt that the vagina plays a
2020-11-09
It is without doubt that the vagina plays a significant role in the perception of coital stimulation leading to sexual arousal and, finally, orgasm. In response to sensory stimulation, relaxation of vaginal vascular and nonvascular smooth muscle occurs, resulting in an increase in local blood flow a
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However in many of the above mentioned studies
2020-11-09
However, in many of the above mentioned studies, the NaCl concentrations in the extraction buffers were different from those used here. For instance, in the study that performed cathepsin D extraction from human AD wehi receptor tissue, the concentration was 150mM [30], while that for the extractio
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br Methods br Results br Discussion With this study we
2020-11-09
Methods Results Discussion With this study, we provided evidence that acriflavine can interfere with EMT and UPR, two well-described pathways associated with cancer aggressiveness. And, because drug resistance is also clearly associated with the mesenchymal state [36], blocking of the epith
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Our studies approached this problem using integrative omics
2020-11-09
Our studies approached this problem using integrative -omics analysis of human NK-ieILC1s from distinct microenvironments and functional subsets, including helper and adaptive phenotypes. At both the transcriptional and epigenetic levels, we find that the adaptive subset, CD57+ cytotoxic NK cells, s
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Given the important regulatory roles Ub
2020-11-09
Given the important regulatory roles Ub signaling pathways play in eukaryotes, bacterial pathogens and viruses have evolved elaborate mechanisms to hijack host Ub signaling pathways and evade the immune response. This is highlighted by the numerous E3 Ub ligases and spectrum of DUBs encoded by bacte
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In the present work we have investigated the reactivity
2020-11-06
In the present work, we have investigated the reactivity of N-aryl-N′-hydroxyguanidines 1a–d (see Scheme 1 for structures) with the water-soluble Cu(II) complex 8. Using EPR and UV–Visible spectroscopy, we have shown that the studied N-aryl-N′-hydroxyguanidines 1a–d can bind and transfer electrons t
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Total synthesis requires the two key intermediates and
2020-11-06
Total synthesis requires the two key intermediates 3 and 7, which were synthesized using the route described in below. Phenylethylamine 3 was readily synthesized from vanillin or isovanillin; the overall yield was 50–52%. To prepare the intermediates 7, bromination of 2-(4-hydroxyphenyl) acetate wi
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br Experimental section br Author contributions
2020-11-06
Experimental section Author contributions Acknowledgements Introduction Many vasoactive intestinal peptide in cells are sequential enzymatic reactions where the product of one enzyme serves as the substrate of a second enzyme (1, 2). Experimental evidence suggests that some of these cons
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In this study for the first
2020-11-06
In this srt2104 study, for the first time, we demonstrated that herb-derived LFS-01 induces concomitant mitophagy and apoptosis in lymphoma cells. Through various biochemical studies, we showed that LFS-01 directly targets the sulfhydryl (-SH) group of a conserved cysteine in the nuclear export sign
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We further verified the presence
2020-11-06
We further verified the presence of CLIC1, CLIC4 and CLIC5 in purified mitochondria following protocols described earlier (Singh et al., 2012). As shown in Fig. 4, CLIC4 and CLIC5 were present in the ultra-pure mitochondrial fraction (M3). All the three fractions obtained from 30% (v/v) Percoll grad
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