• br Results The Hot Start experience and outcomes were embodi

  2018-11-14

  

  Results The Hot Start experience and outcomes were embodied in established and conceived infrastructure provided by its membership. This was both as originally proposed and subsequently informed and amended in the course of operational experience as follows. Discussion The EBiSC Hot Start yie

• The SWI SNF complex consists

  2018-11-14

  

  The SWI/SNF complex consists of 15 core subunits whose unique composition is critical for its distinct functions in different types of cells (Kadoch et al., 2013; Wu et al., 2009). In our study, we demonstrated that both BAF170 and BAF155 existed in the human BRG1-SWI/SNF complex and were enriched w

• The derivation of human induced

  2018-11-14

  

  The derivation of human induced pluripotent stem endopeptidase (hiPSCs) from fibroblasts (Takahashi et al., 2007) offers new opportunities to study XCI in human cells. For mouse fibroblasts, it has been shown that the Xi becomes reactivated during the reprogramming process, followed by random XCI (

• Previously in vitro studies of

  2018-11-14

  

  Previously, in vitro studies of CIPN were performed in rat pheochromocytoma or SK-N-SH human neuroblastoma cell lines as model systems to evaluate decreases in neurite outgrowth in response to neurotoxic chemotherapy drugs, such as paclitaxel, vincristine, oxaliplatin and cisplatin (Rovini et al., 2

• We and others have recently reported the therapeutic benefit

  2018-11-14

  

  We and others have recently reported the therapeutic benefits of propranolol in 2 patients with relapsing metastatic and multi-focal angiosarcoma, respectively (Banavali et al., 2015; Chow et al., 2015). Here, we extended these initial findings to 7 consecutive angiosarcoma patients with dismal prog

• A number of studies have demonstrated that oxidative injury

  2018-11-14

  

  A number of studies have demonstrated that oxidative injury in RPE cultures can be mitigated by compounds that exhibit antioxidant properties, including resveratrol (Chan et al., 2015). In contrast, we observed that piceatannol, a naturally occurring hydroxylated analog of resveratrol, promotes a su

• Hypothalamic hamartoma HH is a rare about

  2018-11-14

  

  Hypothalamic hamartoma (HH) is a rare (about 1:100,000) developmental, non-neoplastic malformation involving the small hypothalamic area located between the infundibular stalk and the mammillary bodies (). HH can be associated with a range of neurological and/or endocrinogical manifestations (). How

• THZ531 Most studies have been focused on investigating the m

  2018-11-14

  

  Most studies have been focused on investigating the molecular control of GPCR ubiquitination by identifying the E3 ubiquitin ligase, while the little information is available for deubiquitination of GPCR by deubiqutinating enzymes. Here we report that a deubiquitinating enzyme, USP11, promotes LPA1

• br Methods br Discussion We systematically searched the lite

  2018-11-14

  

  Methods Discussion We systematically searched the literature from the last five years to identify potential blood biomarkers for cancer (Hanahan & Weinberg, 2011; Cree, 2011). The data mining process retrieved 3990 citations from the initial 19, 724 records, screening the abstracts of these ci

• To date smallpox is the only infectious disease of humans

  2018-11-14

  

  To date, smallpox is the only infectious disease of humans that has been eradicated. A biological factor that favored smallpox eradication is the lack of a nonhuman reservoir. In scopolamine hydrobromide to smallpox, a yaws-like disease has been documented in various species of nonhuman primates (N

• In accordance with these observations we

  2018-11-14

  

  In accordance with these observations, we demonstrated the importance of a newly-identified stress response regulator, Usp2, both in Staphylococcal abscess lesion formation, albeit to a lesser extent than for the rshsyn mutant, and in biofilm formation. This correlates with recent studies that demon

• The complex interplay between viral escape and Env conformat

  2018-11-14

  

  The complex interplay between viral escape and Env conformation observed by Bradley et al. and others gives some pause to reductionist approaches focussing on recapitulating single bNAb specificities by immunisation. Favourable Gefitinib interactions between different bNAb epitopes, shown here for

• In a more than five year

  2018-11-14

  

  In a more than five-year-long study, we used a non-isogenic respiratory chain (RC) deficient mouse strain, namely the Harlequin (Hq) mouse, to test a set of drugs. We previously attributed the Hq mouse phenotype to a partial defect of RC complex I (CI) activity (Vahsen et al., 2004), due to a retrov

• br Data These data mainly focus on

  2018-11-14

  

  Data These data mainly focus on the dose-dependent neuroprotection provided by baclofen, memantine and l-carnitine against oxygen-glucose-deprivation (OGD)-related neurodegeneration of CA1 region, with an addition of the data obtained from the use of hypothermia instead of pharmacological agents.

• Only two studies have investigated

  2018-11-14

  

  Only two studies have investigated whether pubertal factors also influence white matter microstructure in adolescence, in addition to effects of age. The first study looked at RD in white matter tracts in males and females aged 8–28 years (n = 114, 63 females), and explored whether pubertal effects

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