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NPC L NPC Niemann Pick C like like
2020-08-10
NPC1L1 (NPC1 [Niemann-Pick C-like-1]-like intracellular cholesterol transporter) is the rate-limiting transmembrane transporter for cholesterol flavopiridol from the intestinal lumen, and it mediates the absorption of both dietary and biliary cholesterol., , NPC1L1 is the target of the cholesterol-l
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Another potential source of variable affinities
2020-08-10
Another potential source of variable affinities is inherent in the method of RBA determination. While several reports simply use relative IC50 values as RBAs [11], [12], [13], [14], [15], these are only an approximate measure of relative affinity since IC50 varies due to experimental and biological
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Introduction Mycobacterium leprae the causative agent of
2020-08-08
Introduction Mycobacterium leprae, the causative agent of leprosy, affects skin, peripheral nerves and upper respiratory tract [1]. Although leprosy has been eradicated from most of the countries, it still affects approximately a quarter of a million people from India [2]. Details of many bacteriol
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Addition of deoxyuridine to CY cultures led to
2020-08-08
Addition of deoxyuridine to CY11 cultures led to a significant decline in the amount of uracil-DNA (Fig. 5). Deoxyuridine effectively induces the deo operon and is efficiently degraded to uracil and deoxyribose 1-phosphate by the deoA gene product, thymidine phosphorylase; a minor percentage of deox
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The reference standards methyl difluoro dioxolo benzo imidaz
2020-08-08
The reference standards methyl 3-((2,2-difluoro-5-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-]imidazol-6-yl)carbamoyl)benzoate () and -(2,2-difluoro-5-[1,3]dioxolo[4′,5′:4,5]benzo[1,2-]imidazol-6-yl)-3-methoxybenzamide (), and their corresponding desmethylated precursors 3-((2,2-difluoro-5-[1,3]dioxolo[4′,5′:
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Yan et al combined genetic
2020-08-08
Yan et al. combined genetic and pharmacological approaches to determine which EPAC isoform modulates leptin action, and showed that EPAC1 plays a role in energy balance and leptin signaling in vivo[23]. C57BL/6 EPAC1 knockout (EPAC1−/−) mice are more resistant to high-fat diet (HFD)-induced obesity,
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The present study involved LCPD
2020-08-06
The present study involved LCPD patients with age matched healthy controls from an Iranian genetically homogenous population. Our results suggest that the two eNOS 894G > T and −786T > C polymorphisms are associated with increased risk of LCPD. The few available studies supporting this evidence incl
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13148 Functional studies suggested the presence of a cysLT r
2020-08-06
Functional studies suggested the presence of a cysLT1 receptor. We observed an LTD4-induced cytosolic calcium response, albeit one that was very weak by most standards. The magnitude of the average response was partially explained by the low percentage of 13148 showing a very transient response. Be
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In the present study the
2020-08-06
In the present study, the Isorhamnetin of the CYP2C11 gene and the levels of its protein and activity were decreased in rats with liver insufficiency and in rats after induced dysfunction of the serotonergic system during normal liver function. Moreover, serotonergic system dysfunction during liver
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Due to the lack of a precursor
2020-08-06
Due to the lack of a precursor for serotonin, a tryptophan-deficient diet for 3 weeks led to a reduced serum serotonin level and confirmed the successful dysregulation of the peripheral serotonergic system during normal liver function and during liver insufficiency. Concomitant reductions in the lev
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CDK lacks DNA binding domains and nuclear localization seque
2020-08-06
CDK6 lacks DNA-binding domains and nuclear localization sequences, and therefore will probably be transported to the nucleus by a ‘piggy-back’ mechanism and needs to contact its specific sites indirectly through DNA-binding proteins. Besides NF-κB p65, a further candidate transcription factor is PAX
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Furthermore positioning the naphthalene nucleus in d within
2020-08-06
Furthermore, positioning the naphthalene nucleus in 3d within the main active site and forming one IMR-1 with Tyr385 in addition to many hydrophobic interactions with Val349, Leu352, Gly526, Ala527 and Leu531 residues, correlates well with the position and hydrophobic interactions of the trifluorome
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Although retention effects might stem from differences in bo
2020-08-06
Although retention effects might stem from differences in both consolidation and/or recall of extinction memory, prefrontal dopamine – and thereby COMT enzyme AZD1390 sale – might be particularly relevant for consolidation as indicated by studies on endogenous prefrontal dopamine release in rats aft
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The study of Li et al was the
2020-08-06
The study of Li et al. (2009) was the first one using 7 flavonoids as CK2 holoenzyme inhibitors. Afterwards several further research groups undertook more detailed experiments to estimate the inhibitory potential of this class of inhibitors and its derivatives (Golub et al., 2011, Lolli et al., 2012
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Endothelin ET is a regulatory
2020-08-06
Endothelin (ET-1) is a regulatory neuropeptide with widespread distribution in the central nervous system (CNS). ET-1 is produced by endothelial cells in the neomycin sulfate sale and non endothelial cells such as neurons, astrocytes, and glial cells [24]. ET receptors are found in the brain (cereb
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