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nucleoside transporters br Experimental Procedures br Author
2018-11-08
Experimental Procedures Author Contributions Acknowledgments Introduction The cornea is a multilayered, transparent, and avascular structure forming the anterior part of the eye. Its outermost layer, the corneal epithelium, is exposed to the external environment and thereby needs to be r
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enos inhibitor CD is also known as choline transporter like
2018-11-08
CD92 is also known as choline transporter-like protein 1 (CTL1) and its main function is to transport choline, which is then incorporated into phosphatidylcholine (PC), across the cell membrane (Michel and Bakovic, 2009; Nakamura et al., 2010). In vivo, PC is found in the lipid fraction in the calci
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Acknowledgments We are indebted to the Citomics unit
2018-11-08
Acknowledgments We are indebted to the Citomics unit of the IDIBAPS for technical help. This work was supported by grants from the Spanish Ministry of Economia y CompetitividadBIO2011-30299-C02-02 and from CIDEM-Generalitat de CatalunyaVALTEC09-2-0047. and was developed at the Centro Esther Koplowi
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We observed numerous instances where EtOH
2018-11-08
We observed numerous instances where EtOH had a differential effect on the transcriptome and methylome of undifferentiated hESCs compared to EBs, which contain differentiating Sulforhodamine 101 encompassing all somatic cell types (Itskovitz-Eldor et al., 2000) including those of neural and hepati
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The myocardium lacks the basal apical orientation typical of
2018-11-08
The myocardium lacks the basal–apical orientation typical of epithelial organs making it difficult to delineate the precise localization of CSC niches. The epicardial lining has been employed to define anatomically several classes of niches in the adult heart (Castaldo et al., 2008; Di Meglio et al.
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Early studies demonstrated that primitive cells
2018-11-08
Early studies demonstrated that primitive Senexin A Supplier are readily converted into iPSCs (Kim et al., 2008; Kleger et al., 2012; Tsai et al., 2011). Thus, we expected that Lgr5+ cells would be susceptible to reprogramming. Unexpectedly, Lgr5+ cells from HFs and MEFs showed more resistance to ea
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br Materials and methods br
2018-11-08
Materials and methods Resource table. Resource details Fanconi anemia (FA) is caused by genetic defects in the Fanconi anemia pathway (FA-pathway), which is involved in DNA inter-strand cross-link repair. The disease is characterized by progressive bone marrow failure with a significant num
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Phos-tag Acrylamide HLE cells which were not UVB irradiated
2018-11-08
HLE Phos-tag Acrylamide which were not UVB irradiated displayed the characteristic phenotype of small cobblestone-like, tightly packed colonies which co-expressed the putative LESC markers including P63a (Di Iorio et al., 2005) and Cytokeratin15 (Meyer-Blazejewska et al., 2010). The expression of β
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The main drawback of NSC based
2018-11-08
The main drawback of NSC-based anti-tumor therapies is that, despite the effective tumor tropism exhibited by NSCs, only small portions of transplanted cells can migrate towards the tumor. Several recent publications have revealed that 70–80% tumor volume reduction can be achieved in various orthoto
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br Gene editing using ssODNs
2018-11-08
Gene editing using ssODNs as donors Although a remaining loxP or FRT site may in many cases not influence endogenous gene regulation, and the excision of a PB transposon in most cases leads to restoration of the WT sequence, footprintless gene correction using ssODNs as donors is considered as th
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Another remarkable observation of this study
2018-11-08
Another remarkable observation of this study is that ASCL1-iN dna-pk pathway are exclusively excitatory. This is surprising, because ASCL1 is not typically associated with the excitatory neuronal lineage during neural development (Bertrand et al., 2002; Fode et al., 2000; Guillemot et al., 1993; Jo
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Manumycin A br Methods br Author contribution statement br C
2018-11-08
Methods Author contribution statement Competing financial interest Introduction Retinitis pigmentosa (RP) is just one of a group of heterogeneous inherited retinopathies and monogenic disorders that affect thousands of Americans and millions more worldwide (Daiger et al., 2013; Hamel, 20
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AMD-070 Heat shock proteins as molecular chaperones are invo
2018-11-08
Heat shock proteins, as molecular chaperones, are involved in a variety of cellular functions. Apart from their commonly known roles in maintaining protein stability and mediating the assembly and disassembly of protein complexes, recent studies have shown that certain chaperones, including HSPA8, a
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The exogenous addition of osteogenically derived EVs outperf
2018-11-08
The exogenous addition of osteogenically derived EVs outperformed the effect of current osteoinductive strategies in terms of the type and/or intensity of the signaling, with the early activation of the key osteogenic commitment genes SP7 (Figure 3B) and BMP2 (Figure 3C), considered necessary and su
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The CD and CD alleles differ by
2018-11-08
The CD45.1 and CD45.2 HMBA Linker Supplier differ by only five amino acids within the extracellular domain (Zebedee et al., 1991), resulting in epitope changes that permit specific recognition by monoclonal antibodies (Shen, 1981). The majority of the commonly used mouse strains express the CD45.2
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