• br Introduction Liver fibrosis cirrhosis is a global

  2019-05-13

  

  Introduction Liver fibrosis/cirrhosis is a global health problem that leads to morbidity and mortality. Alcohol abuse is one of the most common causes of liver fibrosis/cirrhosis in western developed countries and accounts for more than 50% of cirrhosis cases. Alcoholic liver fibrosis is characte

• br Conclusions and future perspectives br Conflict of intere

  2019-05-13

  

  Conclusions and future perspectives Conflict of interest Author’s contributions Introduction Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two opposing mechanisms involved in regulating the chemical and functional homeostasis of end

• Si al hablar de realismo se alude

  2019-05-13

  

  Si al hablar de “realismo” se alude en verdad angiotensin receptor blocker un determinado tipo de relación entre literatura y realidad, es la pregunta acerca de las características de esta relación la que nos conduce nuevamente a las crónicas de Indias en la medida en que el siglo xvi en Occidente e

• Magall n es muy claro al decir

  2019-05-13

  

  Magallón es muy claro al decir que la aplicación de las políticas neoliberales en América Latina no significaron cohesión social ni la apropiación de la idea “necesaria” de humanidad. “El mayor problema de estos países sigue siendo la pobreza, la desigualdad social y de oportunidades, la desigualdad

• Virgilio Pi era comenz a

  2019-05-13

  

  Virgilio Piñera comenzó ionomycin desafiar las jerarquías del campo intelectual cubano y argentino desde paradigmas de actualidad, que no siempre estaban cruzados por el prestigio y el reconocimiento internacional, lo que desentonaba con las ideas compartidas por los de Orígenes y con las de muchos

• Romiplostim is an Fc fusion protein that

  2019-05-13

  

  Romiplostim is an Fc-fusion protein that augments thrombopoiesis by binding to and activating the thrombopoietin receptor. It is approved for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglo

• Idelalisib demonstrates a dual mechanism of action by

  2019-05-13

  

  Idelalisib demonstrates a dual mechanism of action by inhibiting pro-survival signalling pathways [6], and, like other kinase inhibitors, leads to re-localisation of tumour hcv protease inhibitors by blocking ingress into and promoting egress out of the lymph node into the blood. Release from the p

• This time last year to coincide with March launched a

  2019-05-13

  

  This time last year, to coincide with (March 9), launched a to highlight the rising burden of kidney disease and to encourage research partnerships to address gaps in knowledge and care, including the affordability of such care. Nephrology research and collaboration has come a relatively long way

• br Conclusion br Conflict of

  2019-05-13

  

  Conclusion Conflict of interest Introduction Classically, cancer has been described as a disease involving uncontrolled cell growth. Now, however, it is apparent that cancer growth and metastasis are not solely dependent on the tumor jnk pathway themselves, but involve pathologies in the su

• br Conclusion br Funding br Conflict of interest br

  2019-05-10

  

  Conclusion Funding Conflict of interest Acknowledgments Introduction Ventricular tachyarrhythmias (VTs) are life-threatening events that result in hemodynamic compromise; therefore, patients often require immediate treatment such as electrical cardioversion. Despite appropriate manage

• Of note cases reported by Britton et al

  2019-05-10

  

  Of note, cases reported by Britton et al. and Keung et al. rely on the demonstration of CD7 and TDT along with myeloid markers to classify the blasts as “biphenotypic” [8,9]. Expression of CD3 is not reported by the authors and these cases would not meet the current 2008 WHO criteria for MPAL. Age

• In February a left neck infiltrating purpuric lesion around

  2019-05-10

  

  In February 2013, a left neck infiltrating purpuric lesion around a previous surgical scar (lymph node biopsy) with mild pain was noted. A subsequent skin biopsy revealed metastatic adenocarcinoma, compatible with ampulla of Vater primary, thereby confirming disease progression with skin metastasis.

• Conflicting findings have been reported on the survival and

  2019-05-09

  

  Conflicting findings have been reported on the survival and function recovery between treatments of LSS and amputation in patients with osteosarcoma. Toward this end, a meta-analysis of published clinical trials was performed to compare the clinical efficacy of LSS and amputation treatments in terms

• br A new model of human wellbeing is emerging

  2019-05-09

  

  A new model of human wellbeing is emerging to guide humanity in the Anthropocene. In essence, it recognises that wellbeing depends on enabling every person to lead a life of dignity and opportunity, while safeguarding the integrity of Earth\'s life-supporting systems. The conceptual framework of s

• br Radiofrequency ablation Application of single radiofreque

  2019-05-09

  

  Radiofrequency ablation Application of single radiofrequency 5-ht receptors to the earliest atrial activation site during tachycardia terminated the tachycardia and restored sinus rhythm (Fig. 4). Because the local AF in the SVC continued, we confirmed that isolation of the SVC from the RA had b

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