• Polyubiquitylation leading to proteolytic degradation

  2018-11-05

  

  Polyubiquitylation leading to proteolytic degradation by the 26S proteasome is involved in all aspects of cell physiology. The highly coordinated process ensures the selective and timely turnover of proteins, thereby controlling cellular activity and maintaining cell and tissue homeostasis (Glickman

• We have previously reported that Nef activates and

  2018-11-05

  

  We have previously reported that Nef activates and shuttles activated ADAM17 into extracellular vesicles (EV) (Lee et al., 2013). This occurred through interaction with a multifaceted protein complex termed the Nef-associated kinase complex (NAKC). In more recent results we demonstrated that Nef/ADA

• Given the competing roles described above an

  2018-11-05

  

  Given the competing roles described above, an important question is whether treatment of cancer by autophagy inhibition will lead to neurodegenerative side effects and likewise, that treatment of neurodegenerative diseases with autophagy promoting agents might promote pre-malignant tumors. There are

• a01 br Definition of local product Thilmany et al suggested

  2018-11-05

  

  Definition of local product Thilmany et al. (2008) suggested that the importance of the ‘local food’ movement was manifested by the selection of ‘Locavores’ in 2007 as the word of the year by the New Oxford American Dictionary, which defines the term as a resident who tries to consume food produc

• Another relevant factor that contributes to the development

  2018-11-05

  

  Another relevant factor that contributes to the development of metabolic disturbances associated with sleep restriction is energy expenditure. Individuals who sleep less are more likely to experience fatigue and sleepiness during the day, which may discourage them from daytime physical activity and

• BKM120 Bedtime and wake time were not related to overweight

  2018-11-05

  

  Bedtime and wake time were not related to overweight or obesity in our study, however an EL sleep timing behavior, corresponding to a longer duration of sleep, resulted in a better weight control compared to the others sleep timing behaviors. In a recent Australian cross-sectional study, adolescent

• br Methods br Sleep and immunity For over years

  2018-11-05

  

  Methods Sleep and immunity For over 2000 years the relationship between sleep and immunity has been the subject of discussion. Hippocrates, for example, mentioned the presence of sleepiness during the course of an acute infection [18,20]. Today we know that the interaction between sleep and i

• br Materials and methods Adult Cebus apella males from

  2018-11-05

  

  Materials and methods Adult Cebus apella males from the Tufted Capuchin Procreation Center (UNESP, Campus Araçatuba) were housed in the same conditions, in individual cages and subjected to natural light-dark (LD) cycles. Eleven monkeys were sacrificed at different times (one animal at each time

• br Various modeling and simulation routes In Fig the various

  2018-11-05

  

  Various modeling and simulation routes In Fig. 1 the various routes for modeling/simulation of a gas sensor are identified. Computational software program such as Matlab/Mathematica can be used for simulating chemisorption induced surface bending, surface potential and theoretical verification of

• br Conclusion br Acknowledgments br

  2018-11-05

  

  Conclusion Acknowledgments Introduction Blood typing is important in clinical practice; in particular, ABO and Rh(D) blood typing are commonly performed prior to blood transfusions to prevent hemolysis caused by type mismatched. Manual test methods, including those using a slide or a tube,

• br Introduction Immunosensors are a

  2018-11-05

  

  Introduction Immunosensors are a specific type of biosensors and can be defined as compact analytical devices that yield measurable signals in response to specific antibody–antigen interactions. A large number of immunosensors have been developed using different kinds of transducers that exploit

• The handheld SERS biosensor successfully identified

  2018-11-05

  

  The handheld SERS biosensor successfully identified bacteria at the species level from pure culture and serum samples. Strain level detection was not observed, Fig. 3. Discrimination between bacterial strains is advantageous because many strains of a single species have differences with respect to p

• alkylation of dna br Experimental br Results and discussion

  2018-11-05

  

  Experimental Results and discussion Conclusion A proof of concept direct conversion solid-state alkylation of dna dosimeter was fabricated by combining the large neutron capture cross-section of 10B with the charge trapping attributes of double layer sub-2nm Pt nanoparticles (Pt NPs) in sc

• br Immunolabeling Isolated mitochondria and

  2018-11-03

  

  Immunolabeling Isolated mitochondria and cardiomyocytes (neonatal and adult) were seeded in glass coverslips (0.17-mm thickness) coated with either poly-d-lysine or poly-l-lysine [0.1% (v/v) in PBS], respectively. After, 24h, samples were preloaded with 200nM mitotracker/ER tracker (as described

• Power in the delta frequency band

  2018-11-03

  

  Power in the delta frequency band of the EEG is the predominant frequency in early life as neural activity develops into its adult-like form (Bell, 1998; Stern et al., 2001). Delta oscillations are visible in primitive animal brains (González et al., 1999) and, in humans, have been linked to generat

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