• In summary we suggest that both cofilin

  2023-01-09

  

  In summary, we suggest that both cofilin and gelsolin are essential factors that regulate sperm capacitation and the acrosomal exocytosis by modulating actin. The relationships between activation/inactivation of cofilin and gelsolin suggest that inhibition of cofilin is important for allowing F-acti

• br ACh and ER tests hereafter Spasm provocation tests have

  2023-01-09

  

  ACh and ER tests hereafter Spasm provocation tests have self-limitations to document coronary artery spasm during daily life. In the past reports, ST elevation was reproducible in some patients with variant gap 0 by the administration of ACh or ER. However, we now employ the ER and ACh spasm prov

• p2x In summary we could identify and experimentally confirm

  2023-01-09

  

  In summary, we could identify and experimentally confirm two novel SBEs within the 5-LO promoter and we were able to demonstrate that TGFβ and SMADs stimulate 5-LO promoter activity. Moreover, an elevated 5-LO expression has been linked to different forms of leukaemia. Therefore, the influence of ML

• br Expression of autotaxin in cancer Autotaxin ATX is

  2023-01-09

  

  Expression of autotaxin in cancer Autotaxin (ATX) is a member of the family of NPPs (Nucleotides pyrophosphatases phosphodiesterases (NPP) family with a unique lysophospholipase D (lysoPLD) activity, allowing the synthesis of LPA from lysophospholipid precursors such as the lysophosphatidylcholin

• prostaglandin receptors Chronic inflammation is associated w

  2023-01-09

  

  Chronic inflammation is associated with both initiation and progression of many neoplastic conditions [149], and ATX may be a player in the process. ATX/LPA signaling is positively correlated with the invasive and metastatic potential of several cancers including melanoma, breast cancer, ovarian can

• br Animals Female Sprague Dawley SD rats

  2023-01-09

  

  Animals Female Sprague Dawley (SD) rats, aged 3 months with body weight between 180-210 g were housed in cages and acclimatized to standardized lab conditions (temperature 23 ± 2°C, humidity 50 ± 5% and 12 h light-dark cycles). The rats were fed with standard rodent food pellet (Harlan Diet, Ross

• Along with the improvement of

  2023-01-09

  

  Along with the improvement of the cadmium transport from roots to aerial tissues, as is required for phytoremediation, over-expression of PtoHMA5 also led to the excessive accumulation of cadmium in leaves that was harmful to plant growth and physiological performance. Thus, detoxification of the he

• exemplifies three of the compounds investigated

  2023-01-09

  

  exemplifies three of the compounds investigated in the selection for a candidate drug (CD). Our first criteria was an IC PF-2341066 as such did not show any genotoxicity in the SOS/umu assay, but this does not say anything about any possible genotoxicity of its metabolites or degradation products.

• As previously mentioned when hypoxia treated cells

  2023-01-09

  

  As previously mentioned when hypoxia-treated cells become re-oxygenated they sustain a significant amount of DNA damage which has been attributed to the formation of reactive oxygen species . This finding represents more than just an interesting in vitro phenomenon as within a tumor, cells have been

• shows the complexes resulting from interaction of the propos

  2023-01-09

  

  shows the complexes resulting from interaction of the proposed anion receptors with the anions F, Cl, NO, and SO. No imaginary frequency was observed for the optimized complexes indicating the complexes are in potential minima and they are not transition state structures. summarizes the calculate

• br ASK in Huntington s disease and other polyglutamine disea

  2023-01-09

  

  ASK1 in Huntington's disease and other polyglutamine diseases The polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by the expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats in the coding regions of specific genes, leading to the production

• br Materials and methods br Results br Discussion In this

  2023-01-09

  

  Materials and methods Results Discussion In this study, the orphan receptor GPR25 was cloned from several representative vertebrate species including zebrafish. Although the overall amino AP 18 sequence identity among these species is not high (38–52%), our synteny analysis clearly indicat

• Critically we found that pre treatment with A

  2023-01-09

  

  Critically we found that pre-treatment with Aβ monomer preparations prevented the Aβ oligomer-induced aggregation of PrPC. These preparations contain a mixture of Aβ species and consequently it was not possible to identify the precise form of Aβ that is responsible for this effect. It is possible th

• Ultracentrifugation of AD brain was reported to

  2023-01-09

  

  Ultracentrifugation of AD CHC was reported to remove >99.95% of Aβ, while only reducing seeding capacity by 70% (Langer et al., 2011). This suggests that the most potent seeding Aβ species are relatively small soluble oligomers rather than larger insoluble fibrils. It was also noted that this poten

• The importance of TARPs for AMPAR expression and function

  2023-01-09

  

  The importance of TARPs for AMPAR expression and function was revealed initially in the cerebellum, where the lack of γ-2 in the mutant mice waggler and stargazer (stg/stg) was associated with a selective loss of AMPAR-mediated synaptic currents in cerebellar granule Argatroban (Chen et al., 2000; H

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