• Aldose reductase ALR EC the first enzyme in the polyol

  2024-11-20

  

  Aldose reductase (ALR2, EC1.1.1.21), the first enzyme in the polyol pathway, is a monomeric oxidoreductase that catalyses the NADPH-dependent reduction of a wide variety of carbonyl compounds, especially glucose. In this metabolism pathway, glucose is firstly reduced to sorbitol catalyzed by ALR2 wi

• Based on the observation that antipsychotic drugs increase H

  2024-11-19

  

  Based on the observation that antipsychotic drugs increase 5-HT1A–D2 heteromerization level (Łukasiewicz et al., 2016), we set out to compare the effect of paroxetine to that of risperidone. Paroxetine, a potent SSRI, is very effective in the treatment of depression and anxiety disorders, e.g., gene

• A decrease in lactate concentration in the incubation medium

  2024-11-19

  

  A decrease in lactate concentration in the incubation medium was observed in samples treated with heparin and 2′,5′-dideoxyadenosine compared with the control (0.05; Fig. 2B). Discussion In the present study we compared the oxidative metabolism and intracellular signals of heparin, the glycosami

• Adenosine receptors activate a number of signalling pathways

  2024-11-19

  

  Adenosine receptors activate a number of signalling pathways involved in tissue survival including several mitogen-activated protein kinases (Fredholm et al., 2001). The common feature of all adenosine receptors is the positive coupling to ERK1/2, whilst A2B and A3 receptors can also activate the st

• prostaglandin receptor Changes in actin microfilaments are

  2024-11-19

  

  Changes in prostaglandin receptor microfilaments are mediated by changes in extracellular matrix, mechanical stimulation or growth factors intracellular signaling. We observed significant changes in a number of intracellular signaling pathways associated with changes in actin dynamics during hMSCs

• Cofilin is an additional actin severing protein present in

  2024-11-19

  

  Cofilin is an additional Caspase-1, human recombinant proteinase severing protein present in sperm cells that undergo phosphorylation/inactivation on serine 3 by Lim kinases (LIMK) and by Tes kinases (TESK) [48]. LIMK can be activated by several pathways, including one through the Rho/ROCK/LIMK casc

• In pioneering work from Ikeda and colleagues

  2024-11-19

  

  In 2006, pioneering work from Ikeda and colleagues showed that GMF localizes to and regulates the Gallamine Triethiodide cytoskeleton (see Glossary), and noted its sequence similarity to ADF/cofilin[11]. In 2009, the structure of GMF [6] was solved, revealing it to be a bona fide member of the acti

• hydroxydopamine OHDA is a selective catecholaminergic

  2024-11-19

  

  6-hydroxydopamine (6-OHDA) is a selective catecholaminergic neurotoxin mainly used to generate lesions in the nigrostriatal pathway in rats (Ungerstedt, 1968). The most common use of 6-OHDA is via unilateral injection into the rat medial forebrain bundle (MFB). DA depletion, nigral DA cell loss, and

• Many metalloenzyme inhibitors consist of two chemical

  2024-11-19

  

  Many metalloenzyme inhibitors consist of two chemical components: the MBG, the portion of the inhibitor designed to bind to the metal, and the scaffold, the portion of the inhibitor recognized by the amino lxr agonists residues that form the substrate-binding site of the metalloenzyme. The MGB is o

• Secondly leptin has been shown to enhance

  2024-11-19

  

  Secondly, leptin has been shown to enhance aromatase mRNA expression, aromatase content and its enzymatic activity in epithelial breast cancer Isochlorogenic acid A by inducing promoters II and I.3 via an enhanced binding of transcription activator protein 1 (AP-1) complex to specific DNA sites in

• As the experimental procedure used could reflect agonist sti

  2024-11-19

  

  As the experimental procedure used could reflect agonist-stimulation of both anterograde and retrograde APJ trafficking, as has been described for the δ-opioid peptide receptor (Zhang et al., 2006b, Zhang et al., 2006a), receptor internalization was more directly monitored by loading cell surface HA

• We subsequently performed immunohistochemistry on sections o

  2024-11-19

  

  We subsequently performed immunohistochemistry on sections obtained from mice at 16 weeks after surgery. Type II collagen expression was detected in all articular cartilage zones, but was weak in the upper zone in the vehicle-treated group. MMP-13 and type X collagen expression were increased in the

• Introduction Plant pathogenic fungi are major pathogens in

  2024-11-19

  

  Introduction Plant pathogenic fungi are major pathogens in agricultural diseases and the cause of large crop losses worldwide. There are many kinds of plant pathogenic fungi, with various modes of action. For example, Botrytis cinerea (B. cinerea) is the disease pathogen in the economically importa

• br Materials and method br Results

  2024-11-19

  

  Materials and method Results and discussion Conclusion The adsorption behaviors of 5 antibiotics on 5 types of microplastic particles were investigated using batch type experiments. Our results showed that adsorption capacities varied among antibiotics, plastic types, and environmental cond

• Melphalan Introduction Antimicrobial resistance is a growing

  2024-11-19

  

  Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of Melphalan [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and their knowled

16565 records 50/1105 page Previous Next First page 上5页 4647484950 下5页 Last page