• Laboratory and clinical evidence strongly suggests that muta

  2018-10-30

  

  Laboratory and clinical evidence strongly suggests that mutations of LBD of RARα and B box2 of PML in PML–RARα are responsible for resistance to ATRA and ATO, respectively (Jeanne et al., 2010; Zhang et al., 2010; Goto et al., 2011). However, these mutations generally occur at the time of relapse. P

• From the therapeutic viewpoint the

  2018-10-30

  

  From the therapeutic viewpoint, the best and quick way to address the hurdles of controlling parasitic nematodes lies in the solid understanding of the basic biology of the organism and drawing parallels to targets of approved drugs that already have established safety profiles. This approach of rep

• Socioeconomic characteristics in peoples neighborhoods such

  2018-10-30

  

  Socioeconomic characteristics in peoples\'neighborhoods – such as median level of income and material deprivation – affect individual health through a number of avenues (Riva et al., 2007; Yen et al., 2009; Meijer et al., 2012; Jonker et al., 2015; Schule and Bolte, 2015). Low-SES neighborhoods are

• br PI K Akt mTOR

  2018-10-30

  

  PI3K/Akt/mTOR Pathway Inhibition A number of agents that target various nodes of the phosphoinositide-3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, including PI3K and mTOR inhibitors, are currently in development for the treatment of MPNs. This pathway is a crucial regulator o

• Mechanisms of increased lung cancer susceptibility independe

  2018-10-30

  

  Mechanisms of increased lung cancer susceptibility independent of smoking quantity for individuals with chromosome 15q25.1 high-risk genotypes are not entirely clear. Multiple studies have demonstrated associations between SNPs in chromosome 15q25.1 and lung cancer in nonsmokers (Hung et al., 2008;

• br Gestational trophoblastic diseases GTD

  2018-10-30

  

  Gestational trophoblastic diseases (GTD) are a group of disorders that originate from the trophoblast, which is the outer layer of the RO 4929097 manufacturer that normally gives rise to the placenta and is the first tissue to differentiate from the developing embryos after implantation. The huma

• Excessive inflammation is an early systemic

  2018-10-30

  

  Excessive inflammation is an early systemic inflammatory response that can result in multiple organ failure and even death (Leclerc et al., 2011). miRNAs enriched in exosomes play a pivotal role in regulating inflammation (Wang et al., 2015). miR-155 and miR-146a are two critical regulators of infla

• As the epidemic expands in

  2018-10-30

  

  As the epidemic expands in scale and geographic range, a growing number of travellers are exporting ZIKV to other regions of the world, including Europe, where Aedes vectors are known to be present (Maria et al., 2016; Zammarchi et al., 2015; http://ecdc.europa.eu/en/healthtopics/vectors/vector-maps

• br Experimental design materials and methods The details of

  2018-10-29

  

  Experimental design, materials and methods The details of the sites have been described in our previous study [1]. In brief, the dataset collections order AZD1152-HQPA localized in Kenya and Tanzania. In Kenya, was situated in Taita Hills in South-Eastern Kenya (coastal region), between latitude

• br Specifications Table Experimental design materials

  2018-10-29

  

  Specifications Table . Experimental design, materials and methods Measurements were taken by a special team of 2 trained assistants, while other information was taken from the RLMS survey which contains questions regarding an individual׳s socioeconomic characteristics and family background [1].

• Studies examining attention bias towards happy faces

  2018-10-29

  

  Studies examining attention bias towards happy faces are scarce. In the internalizing literature, increased attention towards happy faces is most commonly conceptualized as reflecting a bias towards rewards. Evidence suggesting that happy faces may be socially rewarding comes from fMRI studies in wh

• In the second study Moser et al

  2018-10-29

  

  In the second study, Moser et al. (2011) examined ERPs elicited immediately after the response in a very simple two-choice flanker task among college students. Two well-known and dissociable ERPs are elicited after errors in such tasks − the error-related negativity (ERN; Gehring et al., 1993) and e

• Nussbaum se pregunta por qu est mal visto recibir dinero

  2018-10-29

  

  Nussbaum se pregunta por qué está mal visto recibir dinero o hacer contratos en relación al uso de ciertas partes del cuerpo. Los argumentos feministas en contra de la prostitución califican las transacciones mercantiles en el campo de la sexualidad femenina como denigrantes para las mujeres, y dice

• Este n mero abre con los

  2018-10-29

  

  Este número abre con los “hasta prontos”. Marta Lamas, Hortensia Moreno, Jean Franco y Dora Cardaci han escrito cada una include su manera su texto de una despedida que no lo es (dice Lamas). O que sí (llora Jean Franco). Un hasta luego, dice Cardaci. Un pretexto para hacer balance (Moreno). Cada un

• br El reto de la realidad emp rica Si

  2018-10-29

  

  El reto de la realidad empírica Si bien la discusión conceptual sobre el género transcurría más allá de las fronteras mexicanas, ese era ya el contexto que enmarcaba la investigación sobre El orden discursivo de género en Los Altos de Jalisco (Palomar, 2005), con la cual terminé mis estudios de d

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