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SP 600125 Fatty acid amide hydrolase FAAH is a membrane boun
2022-04-09
Fatty SP 600125 amide hydrolase (FAAH) is a membrane-bound enzyme which releases arachidonic acid and ethanolamine by breaking amide bond of AEA. It also controls the cellular uptake of AEA, by creating and maintaining an inward concentration gradient leading to AEA-facilitated diffusion via a spec
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Our observation of LPS induced increase
2022-04-09
Our observation of LPS-induced increase in the sensitivity of cultured endothelium-intact coronary annexin v towards stimulation with selective ETB receptor agonist (S6c) could be explained by activation of TLRs receptors located on the endothelium of rat coronary arteries. However, the possible rec
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MK cyclobutylpiperidin yl oxyphenyl methyl trifluoromethyl
2022-04-09
MK-3134 (3-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-2-methyl-5-(trifluoromethyl)quinazolin-4-one) was synthesized by Merck, as the structurally constrained analogue of MK-0249 (Nagase et al., 2008). This H3R inverse agonist has MW 457.49, seven HBA, and MLogP 4.58, with one violation in terms of dr
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br Obesity tips to a systematic failure in
2022-04-09
Obesity tips to a systematic failure in the overall metabolic regulation; it is a major global health problem and is linked to several metabolic diseases such as (T2D) (see ), (NAFLD), and cardiovascular disorders. The prevalence of such metabolic disorders has increased dramatically worldwide ,
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br Acknowledgments This research was partially supported by
2022-04-08
Acknowledgments This research was partially supported by the National Key Research and Development Program of China (2018YFD1000800); the National Natural Science Foundation of China (No. 31872943; No. 31501779 and No. 31372059>); 12th Five-Year State Science and Technology Support Program (2014B
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Materials and Methods br Results br Discussion Activation of
2022-04-08
Materials and Methods Results Discussion Activation of TLRs by damage-associated patterns is a well-recognized trigger for inflammation. TLR ligation results in a large increase in glycolytic metabolism in macrophages and other immune cells,12, 27 and we hypothesized that the glycolytic metab
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The mD plasmid containing CD domain
2022-04-08
The mD1.2 plasmid containing CD4 domain 1 gene under the control of a promoter was obtained as a gift from Dr. Dimiter S. Dimitrov. The mD1.2 plasmid was digested using restriction endonuclease I (New England BioLabs, USA) to release the mD1.2 gene. The gene encoding the mD1.2 protein was elongated
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It has been found that WHI
2022-04-08
It has been found that WHI-P131, a JAK3 inhibitor, induced apoptosis of CD4+ T calcium calmodulin dependent protein kinase (Cetkovic-Cvrlje et al., 2012). Also, other JAK3 inhibitors (AG490 and WHI-P154) caused apoptosis in anaplastic large cell lymphoma (Amin et al., 2003). Taking into account the
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br Acknowledgments br Introduction Oocyte donation has incre
2022-04-08
Acknowledgments Introduction Oocyte donation has increasingly been used as an option for infertile women with preserved ovarian function but expected poor outcomes, e.g. low responders to standard ovarian stimulation and women who have experienced repeated implantation failure. Transfer of emb
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In conclusion we have designed and
2022-04-08
In conclusion, we have designed and characterized a novel series of EAAT-blockers, exemplified by (-[4-(2-bromo-4,5-difluorophenoxy)phenyl]--asparagine)—a potent, selective, competitive non-substrate inhibitor of EAAT-2. As one of the most potent and selective EAAT-2 inhibitors identified to date,
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Ca independent release of L C glutamate and
2022-04-08
Ca2+-independent release of L-[14C]glutamate and [3Н]GABA that occurs via transporters working in the reverse mode also insignificantly increased in vitamin D3 deficiency despite decreased GAT-3 and EAAC-1 ddr1 and neurotransmitter uptake efficacy Fig. 3, Fig. 6 A). However, the upward tendency in G
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Gli signaling pathways play critical roles in embryonic and
2022-04-08
Gli signaling pathways play critical roles in embryonic and postnatal lung development [22]. Many reports suggest that wound healing and fibrotic diseases involve activation of pathways used during development [23]. In the adult lung, Gli signaling activity measured by Gli1 expression is restricted
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br Materials and methods br Results br Discussion
2022-04-07
Materials and methods Results Discussion Although homologues of the β-galactosidase gene were known to exist in the Xenopus genome, and SA-β-gal activity has been detected in whole-mount Xenopus embryos by histochemical staining (Davaapil et al., 2017), no reports have been presented so far
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Colorectal cancer CRC is the
2022-04-07
Colorectal cancer (CRC) is the third most common cancer in men and the second in women worldwide and almost 55% of the cases occur in more developed areas of the world. In the 2012, more than 1.3 million new cases were reported, which accounts for about 10% of the total cancers worldwide (GLOBOCAN,
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Recently Bristol Myers Squibb and
2022-04-07
Recently, Bristol-Myers Squibb and Merck reported their GPR40 agonist research focused on the modification of α,β-position of phenylpropionic sphk derivatives. For example, in recent published patent applications, Bristol-Myers Squibb claimed the pyrrolidine and dihydropyrazole GPR40 agonists with
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