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In summary our results support the
2021-11-18
In summary, our results support the model that the histone demethylase KDM5 is a critical host transcriptional regulator that maintains immune homeostasis and is responsible for preservation of the normal commensal microbial community structure and behavior. Neurodevelopmental disorders such as ID a
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The components of the SAGA complex including Gcn
2021-11-18
The components of the SAGA complex including Gcn5 have recently been found to be involved in regulating pathways that are required for development and virulence in different species under the environmental stresses, around 10% of S. cerevisiae genes are activated by the transcriptional coactivator S
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Tumor specific CD cytolytic T lymphocytes CTLs recognizing t
2021-11-18
Tumor-specific CD8+ cytolytic T lymphocytes (CTLs) recognizing tumor antigenic peptide/major histocompatibility complexes-I (pMHC-I) presented on tumor cells play an important role in antitumor immunity [12]. However, immune tolerance including central (natural) or peripheral (acquired) tolerance be
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br Conflict of interest br Funding This work was
2021-11-18
Conflict of interest Funding This work was supported by the National Institutes of Health MSK Cancer Center Support Grant/Core Grant [P30 CA008748]. The funding source had no involvement in the study design; in the collection, analysis and interpretation of data; in the writing of the report;
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The increased levels of proinflammatory cytokines in BALF
2021-11-18
The increased levels of proinflammatory cytokines in BALF are noted during ALI/ARDS, and the persistent elevation of these mediators may exaggerate systemic or focal inflammatory reaction with a worse outcome. These cytokines, particularly TNF-α and IL-6, play essential roles in ALI [16,17]. The ove
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br Materials and methods br Results br Discussion D abbrevia
2021-11-18
Materials and methods Results Discussion D. abbreviatus larvae are voracious feeders, and the nutrients consumed as part of their diet are broken by gut proteases and utilized for growth and development. Since proteases play an important role in larval and adult food digestion, it is import
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The stud http www apexbt com
2021-11-18
The study was supported by Science Foundation for the Youth Scholars of Hubei Provincial Department of Education for Science and technology research program (No.: Q2017007). Introduction Chlorpyrifos is an organophosphate (OP) insecticide widely used in a variety of food crops to control a great
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br Acknowledgments This research was partially
2021-11-18
Acknowledgments This research was partially supported by the National Key Research and Development Program of China (2018YFD1000800); the National Natural Science Foundation of China (No. 31872943; No. 31501779 and No. 31372059>); 12th Five-Year State Science and Technology Support Program (2014B
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br Introduction Atherosclerosis is a
2021-11-18
Introduction Atherosclerosis is a chronic inflammatory disease characterized by lipid and leukocyte accumulation within the arterial wall. Homocysteine (Hcy) is a thiol-containing amino NSC 319726 derivative derived from the metabolism of dietary methionine. Epidemiological studies have shown th
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Alzheimer s disease AD is a neurodegenerative disorder
2021-11-18
Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the presence of abnormal filamentous protein inclusions in nerve cells of the brain [2]. The neuropathological hallmarks of AD were first reported by Alois Alzheimer and date back to 1907 [3], [4]. These inclusions are for
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Asiaticoside Lactate LA the end product of aerobic glycolysi
2021-11-18
Lactate (LA), the end product of aerobic glycolysis, has been long neglected and seen as a byproduct until recently the findings for its important role in global gene transcription, cancer progression, functional polarisation of immune Asiaticoside and the sustenance of stem cells [[7], [8], [9]].
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Apart from the different assays used biased agonism could al
2021-11-18
Apart from the different assays used, biased agonism could also explain the inconsistent pharmacology of GPR55. Indeed, one study compared the effect of LPIs and Virodhamine in HEK293 Bufalin stably transfected with human GPR55. They found that the effect of both ligands on intracellular Ca2+ was b
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Limited efforts were made to exploit the naturally occurring
2021-11-17
Limited efforts were made to exploit the naturally-occurring antigen-specific Treg for ex vivo expansion. This study sets up a reproducible protocol for the expansion of insulin-specific Treg isolated from NOD mice. These Deoxycorticosterone acetate exhibited higher suppressive capacity compared to
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br Signaling pathways activated by pulsatile
2021-11-17
Signaling pathways activated by pulsatile GnRH In the pituitary, GnRH acts by binding to the G protein-coupled GnRHR on the cell surface of the gonadotrope, inducing interaction of the receptor with heterotrimeric G proteins and catalyzing GTP-GDP exchange on the G protein α subunit (Lambert, 200
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br MUTYH associated polyposis br MUTYH and its
2021-11-17
MUTYH-associated polyposis MUTYH and its metal cofactors MUTYH harbors two vital cofactors, both of which are located remotely from the active site (Fig. 6). One of these cofactors, a [4Fe-4S]2+(Fe-S) cluster, is chelated by four Cys residues in the N-terminal domain, and positions an Fe-S clu
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