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br Application of TIRFM to visualizing exocytosis TIRFM was
2021-11-15
Application of TIRFM to visualizing exocytosis TIRFM was first used to visualize exocytosis from large secretory granules from chromaffin Meleagrin (Steyer et al., 1997). Before that, visualization of secretory organelle was strictly limited to a few exceptions, such as mast cell of mutant mice,
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SETDB is ubiquitously expressed in
2021-11-15
SETDB1 is ubiquitously expressed in mouse tissues, and more than 900,000 ERVs are dispersed through the mouse genome. Nevertheless, the repertoire of ERVs under the control of SETDB1 was limited and highly cell-type specific. Only 17,349 ERVs were associated with H3K9me3 domains in Th2 cells. The va
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All these recent results show the
2021-11-15
All these recent results show the interconnection between the Hippo pathway as a tumor-suppressor on the one hand and its function as regulator of metabolic homeostasis on the other. Disruption of the Hippo pathway leads to cancer growth, which is often associated with pathological disturbances in t
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In the present study fasting blood glucose and insulin
2021-11-15
In the present study, fasting blood glucose and insulin levels were not significantly different between GA patients and control cases. Normal mammalian cells typically acquire fatty acids from the circulation owing to insulin, which is the most lipogenic hormone in the subset of adult tissues, inclu
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Freinkel first reported in the late s
2021-11-15
Freinkel first reported in the late 1960s that maternal hypertriglyceridemia benefits the fetus during starvation by increasing maternal consumption of triglyceride for ketone body synthesis giving the basis for “accelerated starvation” theory [4,5]. This maternal metabolic reprogramming during peri
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br Materials and methods br Results br Discussion D abbrevia
2021-11-15
Materials and methods Results Discussion D. abbreviatus larvae are voracious feeders, and the nutrients consumed as part of their diet are broken by gut proteases and utilized for growth and development. Since proteases play an important role in larval and adult food digestion, it is import
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Under most circumstances NO is
2021-11-15
Under most circumstances, NO is a potent endogenous vasodilator. Therefore, its involvement in an endothelium-dependent contraction seems paradoxical, to say the least. Soluble guanylyl cyclase (sGC) is the major downstream target of NO; its inhibition results in the lack of vasoconstrictor response
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Cdc is also linked to the adherens junction
2021-11-15
Cdc42 is also linked to the adherens junction via IQGAP1, however, it appears to have an opposite effect on junctional stability. When Cdc42 is inactive, IQGAP1 binds to β-catenin, displacing α-catenin, resulting in the loss of α-catenin-linked 7026 filaments from the adherens junction and reduced
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br Conflict of interest br Transparency document br Acknowle
2021-11-12
Conflict of interest Transparency document Acknowledgements We acknowledge our funding sources from the American Heart Association (13EIA4480016) and the National Institute of Health/National Heart, Lung, and Blood Institute (RO1 HL094414). We are very grateful to Dr. Shaohua Xiao and Dr. S
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br Materials and methods br Results and discussion
2021-11-12
Materials and methods Results and discussion Conclusion Altogether, our data provide an unexpected insight into Cx26 trafficking pathway and gap junction assembly in the cochlea. Since many of the disease-causing mutations in GJB2 impair the trafficking and delivery of Cx26 to the cell surf
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br Therapeutic approaches exploiting Cx function
2021-11-12
Therapeutic approaches exploiting Cx43 function Due to their potential role in cancer metastasis, attempts have been made to alter connexin function to inhibit cancer growth. Therapeutic approaches include Cx43 peptide mimetics, Cx43 inhibitors, chemical agents capable of enhancing Cx43 function,
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br Role of FPRs in regulating the
2021-11-12
Role of FPRs in regulating the inflammatory response Annexin I is a glucocorticoid-regulated protein possessing both pro- and anti-inflammatory activity that might be mediated, in part, by FPR activation [35]. Expressed in a variety of cell types, annexin I is particularly abundant in neutrophils
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Next we were interested in replacing the ketobenzimidazole f
2021-11-12
Next, we were interested in replacing the ketobenzimidazole fragment of our inhibitors with a noncarbonyl bearing heterocycle. We reasoned that if we could replace the carbonyl while maintaining comparable FAAH inhibition, it would provide evidence for a noncovalent mechanism of action. Thus, we eva
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Previous evidence suggests that PRC is
2021-11-12
Previous evidence suggests that PRC2 is an important regulator of chromatin looping interactions in embryonic stem NS 1738 sale . The new study by Donaldson-Collier and colleagues provides the first evidence that similar processes may be at play in lymphoma. It is still largely unclear, however, bo
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Consistent with a similar study we found
2021-11-12
Consistent with a similar study, we found economic status to be very important to domestic funding of HIV. Upper-middle-income and high-income countries are more likely to have fiscal space for health and be less reliant on external sources. Moreover, richer countries often attract larger cofinancin
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